- Production Method for 1,2,2,2-Tetrafluoroethyl Difluoromethyl Ether (Desflurane)
-
Fluoral is obtained by gas-phase fluorination of chloral in the presence of a catalyst and then reacted with trimethyl orthoformate, thereby readily forming 1,2,2,2-tetrafluoroethyl methyl ether as an intermediate for production of desflurane. 1,2,2,2-Tetrafluoroethyl difluoromethyl ether (desflurane) is produced with high yield from the thus-formed 1,2,2,2-tetrafluoroethyl methyl ether by chlorination and fluorination. This method enables efficient industrial-scale production of desflurane useful as an inhalation anesthetic
- -
-
Paragraph 0166-0167; 0170; 0173
(2019/11/22)
-
- Asymmetric Synthesis of the Volatile Anesthetic 1,2,2,2-Tetrafluoroethyl Chlorofluoromethyl Ether Using a Stereospecific Decarboxylation of Unusual Stereochemical Outcome
-
Acid 1 is optically resolved by diastereomeric amide formation/chromatography/hydrolysis.Decarboxylaion of the enantiomers of acid 1 gives the enantiomers of ether 2 with a very high degree of stereospecificity.The absolute configurations of both the star
- Rozov, Leonid A.,Rafalko, Patrice W.,Evans, Suzanne M.,Brockunier, Linda,Ramig, Keith
-
p. 1319 - 1325
(2007/10/02)
-