Preparation and purification method of 5-ethyl-5-isoamyl malonyl urea
The invention provides a preparation and purification method for preparing 5-ethyl-5-isoamyl malonyl urea. The preparation and purification method has the advantages of stable process, no special requirements on the concentration of sodium methoxide, direct use of industrial products in the reaction process, easy control of reaction conditions, short reaction time, simple operation, less three wastes, good product quality, high yield, effective reduction of the impurity content, improvement of the quality of the target product, low production cost, and suitableness for industrial production.
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Paragraph 0016-0027
(2020/09/12)
Competition between two metabolic pathways: oxidation and desulfuration in the thiobarbiturate series
In order to study the competition between hepatic hydroxylation and desulfuration in the thiobarbiturate series, two compounds bearing a branched side chain with a tertiary carbon atom in position ω-1 were administered to rats over about one week.Urine and faeces were collected and extracted.The metabolites isolated were identified.It was shown that desulfuration was not the major metabolic pathway, and that, when it took place, it remained a minor process and was accompanied by γ-hydroxylation into a tertiary alcohol. thiobarbiturate series / metabolism / oxidation / desulfuration
Yebga, A.,Menager, S.,Verite, P.,Farnoux, C. Combet,Lafont, O.
p. 769 - 778
(2007/10/03)
Synthesis and cyclization of dialkylmalonuric esters