- New approach for determination of sulfadiazine in pharmaceutical preparations using 4(4-sulphophenylazo)pyrogallol: Kinetic spectrophotometric method
-
A new trend describes the development and validation of a simple, sensitive and selective kinetic spectrophotometric methods for the determination of sulfadiazine in pharmaceutical formulations has been conducted. In this paper, sulfadiazine was derivatiz
- Naser, Naser A.,Alasedi, Kasim M.,Khan, Zainab A.
-
-
Read Online
- Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents
-
In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.
- Abdel-Aziz, Hatem Abdel-Kader,Eldehna, Wagdy Mohamed,Fares, Mohamed,Elsaman, Tilal,Abdel-Aziz, Marwa Mostafa,Soliman, Dalia Hussein
-
p. 1617 - 1630
(2015/11/24)
-
- Polymer complexes: XLXII-interplay of coordination π-π Stacking and hydrogen bonding in supramolecular assembly of [sulpha drug derivatives-N,S:N,O] complexes
-
A novel series of nickel(II) polymer complexes of 5-sulphadiazineazo-3- phenylamino-2-thio-4-thiazolidinone (HL1), 5-sulphamethazine-3- phenylamino-2-thioxo-4-thiazolidinone (HL2), 5-sulphamethoxazole-3- phenylamino-2-thioxo-4-thiazo
- El-Sonbati,Diab,El-Halawany,Salam
-
experimental part
p. 755 - 766
(2011/01/07)
-
- ANTIBACTERIAL ACID DYES AND METHOD OF PREPARING THE SAME AND ANTIBACTERIAL FIBER DYED THEREBY
-
Disclosed are antibacterial acid dyes comprising two identical sulfonamide based antibacterial compounds bonded to acidic dyes by diazotization-coupling reaction, the antibacterial compounds of which have strong antibacterial properties, and a method of p
- -
-
Page/Page column 14-16
(2008/12/08)
-
- Synthesis of some New Pyrazolin-5-ones
-
Synthesis of some sufonamoylhydrazonopyrazolin-5-ones have been reported.
- Jain, Rajeev,Gupta, Seema
-
p. 325 - 325
(2007/10/03)
-