- BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING SAME
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Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1 ), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.
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- New Syntheses of Polyaza Derivatives. Crystal Structure of Pyridazine-3,6-dicarboxylic Acid
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A new route allowing the synthesis of pyridazine-3,6-dicarboxylic acid in preparative quantities is described.The crystal structure of this compound is reported.Several polyaza derivatives were prepared and their structures determined by spectroscopic methods (ir, 1H and 13C nmr).
- Sueur, Stephane,Lagrenee, Michel,Abraham, Francis,Bremard, Claude
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p. 1285 - 1289
(2007/10/02)
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