- The suzuki-miyaura reaction performed using a palladium-n-heterocyclic carbene catalyst and a weak inorganic base
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N-Heterocyclic carbenes (NHCs) have been shown to be useful ligands for the Suzuki-Miyaura cross-coupling at low catalyst loadings. We now report that the commercially available and air-stable [Pd(IPr)(cin)Cl] pre-catalyst permits the formation of various functionalized biaryls from aryl chlorides and boronic acids (37 examples) under very mild conditions using a mixture of ethanol/water as solvent and an inorganic base. [Pd(IPr)(cin)Cl] permits an operationally simple Suzuki-Miyaura reaction under very mild conditions using a mixture of ethanol/water as solvent and an inorganic base.
- Izquierdo, Frédéric,Corpet, Martin,Nolan, Steven P.
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supporting information
p. 1920 - 1924
(2015/03/18)
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- Monodispersed and stable nano copper(0) from copper- aluminium hydrotalcite: Importance in C-C couplings of deactivated aryl chlorides
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A simple one-step approach for the preparation of highly monodispersed nano copper(0) stabilized on alumina [Cu(0)/Al2O3] by thermal reduction of copper-aluminium hydrotalcite (Cu-Al HT) under a hydrogen atmosphere is described. The transformation of Cu-Al HT to Cu(0)/Al 2O3 occurrs via dehydroxylation of divalent and trivalent metal hydroxides and decarboxylation of carbonate anions present in the interlayers of hydrotalcite, as confirmed by XPS, XANES, XRD and TEM analysis. Cu(0)/Al2O3 nano composites were used as an efficient catalyst in the C-C coupling of deactivated aryl chlorides. The high efficiency and reusability exhibited by Cu(0)/Al2O3 outline its potential as an alternative over traditional noble metal-based catalysts in C-C coupling reactions. Copyright
- Arundhathi, Racha,Damodara, Dandu,Mohan, Kakita Veera,Kantam, Mannepalli Lakshmi,Likhar, Pravin R.
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supporting information
p. 751 - 756
(2013/04/10)
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- Dynamics of the glycosidic bond: Conformational space of lactose
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The dynamics of the glycosidic bond of lactose was studied by a paramagnetic tagging-based NMR technique, which allowed the collection of an unusually large series of NMR data for a single compound. By the use of distance- and orientation-dependent residual dipolar couplings and pseudocontact shifts, the simultaneous fitting of the probabilities of computed conformations and the orientation of the magnetic susceptibility tensor of a series of lanthanide complexes of lactose show that its glycosidic bond samples syn/syn, anti/syn and syn/anti φ/I regions of the conformational space in water. The analysis indicates a higher reliability of pseudocontact shift data as compared to residual dipolar couplings with the presently available weakly orienting paramagnetic tagging technique. The method presented herein allows for an improved understanding of the dynamic behaviour of oligosaccharides. Copyright
- Erdelyi, Mate,D'Auvergne, Edward,Navarro-Vazquez, Armando,Leonov, Andrei,Griesinger, Christian
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experimental part
p. 9368 - 9376
(2011/10/09)
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- Photoactivatable HNO-releasing compounds using the retro-Diels-Alder reaction
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We synthesized hetero-Diels-Alder cycloadducts from acyl nitroso derivatives and 9,10-dimethylanthracene, to be photo-inducible HNO-releasing agents and found that introduction of conjugated nitroaromatic groups effectively enhanced the responsiveness of HNO release to UV-A irradiation; we confirmed photoinduced HNO formation by EPR and GCMS analysis. The Royal Society of Chemistry.
- Adachi, Yusuke,Nakagawa, Hidehiko,Matsuo, Kazuya,Suzuki, Takayoshi,Miyata, Naoki
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supporting information; experimental part
p. 5149 - 5151
(2009/03/11)
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- Heterobifunctional pan-selectin inhibitors
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Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
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Page/Page column 12
(2010/11/26)
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- Use of functionalized onium salts as a soluble support for organic synthesis
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The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A1+, X1?, wherein A1+ represents a cation and X1? represents an anion.
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Page/Page column 51
(2010/11/25)
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- HETEROBIFUNCTIONAL COMPOUNDS FOR SELECTIN INHIBITION
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Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
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Page/Page column 25
(2008/06/13)
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- SPECIFIC ANTAGONIST FOR BOTH E- AND P-SELECTINS
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Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a particular glycomimetic linked to a particular BASA (Benzyl Amino Sulfonic Acid).
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Page/Page column 20; 15/22
(2010/02/11)
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