- MULTIPLE KINASE PATHWAY INHIBITORS
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Kinase with inhibitory activity against kinases disposed in multiple signaling pathways and their therapeutic uses.
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Page/Page column 295
(2014/04/17)
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- Sulfanyl substituted phenyl methanones
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The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.
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Page/Page column 9
(2008/06/13)
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- Substituted phenyl methanones
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The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R4, R5, and R6 are as defined
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Page/Page column 29
(2008/06/13)
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- Heterocyclic-substituted phenyl methanones
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The present invention relates to compounds of formula I wherein R1, R2, and are defined in the specification and to pharmaceutically acceptable acid addition salts thereof.
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Page/Page column 64
(2008/06/13)
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- Metalation reactions. XV. Regioselective metalation of (alkylthio)fluorobenzene
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In reactions of (alkylthio)fluorobenzenes with n-butyllithium the compounds 4-RSC6H4F (R = Me, iPr) and 2-iPrSC6H4F were found to undergo metalation selectively ortho to the fluorine atom, whereas 2-MeSC6H4F undergoes metalation at the thiomethyl carbon atom.
- Cabiddu, S.,Fattuoni, C.,Floris, C.,Gelli, G.,Melis, S.
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