- Preparation method of N(pi)-methyl-L-histidine derivative and application thereof to synthesis of whale carnosine
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The invention relates to a preparation method of an N(pi)-methyl-L-histidine derivative and a method for preparing anserine from the synthesized N(pi)-methyl-L-histidine derivative. By the preparationmethod, raw materials are cheap and easy to obtain, the selectivity is good and the yield is high; the operation is simple and easy to implement, a technology is stable, the control is easy, treatment after a reaction is convenient, the product yield is good, the purity is high, and the preparation method can be economically and conveniently applied to industrial production.
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- Concise Synthesis of Anserine: Efficient Solvent Tuning in Asymmetric Hydrogenation Reaction
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A concise synthesis of anserine and related compounds was accomplished by Et-DuPhos-Rh-catalyzed asymmetric hydrogenation of dehydrohistidine derivatives in 2,2,2-trifluoroethanol, which played a key role in improving the yield and selectivity.
- Yamashita, Megumi,Shimizu, Keita,Koizumi, Yasuaki,Wakimoto, Toshiyuki,Hamashima, Yoshitaka,Asakawa, Tomohiro,Inai, Makoto,Kan, Toshiyuki
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p. 2734 - 2736
(2016/11/30)
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- Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues
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We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives. Copyright
- Jain, Rahul,Singh, Jatinder,Perlman, Jeffery H,Gershengorn, Marvin C
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p. 189 - 194
(2007/10/03)
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