- PYRAZOLE COMPOUNDS AS JAK INHIBITORS
-
The present invention relates to compounds of formula (I), wherein R1, R2, R1a, R1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
- -
-
Page/Page column 38
(2011/11/13)
-
- Practical Synthesis of Sultams via Sulfonamide Dianion Alkylation: Application to the Synthesis of Chiral Sultams
-
(Equation presented) A practical synthesis of sultams was developed via intramolecular sulfonamide dianion alkylation. This method has been applied toward the synthesis of chiral sultams, which are synthetically valuable as chiral auxiliaries.
- Lee, Jaemoon,Zhong, Yong-Li,Reamer, Robert A.,Askin, David
-
p. 4175 - 4177
(2007/10/03)
-
