- 7 (2 Aminomethylphenylacetamido) 3 (1 carboxymethyltetrazol 5 ylthiomethyl)3 cephem 4 carboxylic acid
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The synthesis of 7 (2 aminomethylphenylacetamido) 3 (1 carbomethyltetrazol 5 ylthiomethyl) 3 cephem 4 carboxylic acid (BL S786) is described and the antimicrobial activities are compared with cefazolin and cefamandole. The compound exhibits broad antimicrobial spectrum, produces high intramuscular blood levels in mice and demonstrates a high degree of therapeutic efficacy in experimental bacterial infections in rodents.
- Gottstein,Kaplan,Cooper,Silver,Nachfolger,Granatek
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- Photographic material containing a novel DIR-compound
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Photographic elements and processes are described which employ compounds capable of releasing, as a function of silver halide development, a deactivatable development inhibitor to provide a combination of desirable sensitometric results. The deactivatable
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- 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido] cephalosporins
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A 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido] cephalosporin derivative of the formula; STR1 wherein R3 is hydrogen or a residue of a nucleophilic compound; R2 NH is an amino group which may optionally be protected, pharmaceutically acceptable salt or ester thereof, is found to have excellent anti-bacterial activity against a broad spectrum of bacteria inclusive of gram-negative bacteria such as Escherichia coli, Serratia marcescens, Proteus rettgeri, Enterobacter cloacae and Citrobacter freundii. Thus, this compound may be used for an antibacterial agent in therapeutical purposes.
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- 7-[2-(2-Imino-4-thiazolin-4-yl)-2-(syn)-hydroxy-iminoacetamido]-cephalosporins
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Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: STR1 wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.
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- New broad spectrum alkylthio cephalosporins
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A series of 7 substituted alkyl thio acylaminocephalosporins were prepared and tested for in vitro antibacterial activity. The authors tried in their research to find any relationship between antibacterial activity and pharmacokinetic properties on the one hand, and chemical structure on the other. The most interesting products were also studied for their in vivo antibacterial activity in experimental acute systemic infections in the mouse.
- Nannini,Molgora,Biasoli
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p. 343 - 352
(2007/10/05)
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