Radical cyclisation onto imidazoles and benzimidazoles
New synthetic methodology has been developed for the synthesis of [1,2- a]fused imidazoles and benzimidazoles using intramolecular homolytic aromatic substitution. In the intramolecular substitution, N-(ω-alkyl) radicals are generated using Bu3SnH from N-(ω-phenylselanyl)alkyl side chains. Phenylselanyl groups are used as radical leaving groups to avoid problems in the N-alkylation of imidazoles and benzimidazoles. Arylsulfones for imidazoles, and phenylsulfides for benzimidazoles, are used at the leaving groups in the homolytic substitutions.
Aldabbagh, Fawaz,Bowman, W. Russell
p. 4109 - 4122
(2007/10/03)
Radical cyclisation onto imidazoles and benzimidazoles
A new protocol for the synthesis of [1,2-a]-fused benzimidazoles and imidazoles has been developed using intramolecular homolytic aromatic substitution via ω-alkyl radicals generated from 1-(ω-benzeneselenylakyl)-2(benzenesulfenyl)- benzimidazoles and -2-(p-toluenesulfonyl)imidazoles.
Aldabbagh, Fawaz,Bowman, W. Russell
p. 3793 - 3794
(2007/10/03)
Condensation of Lactams with 2-Aminoacetylaldehyde Diethyl Acetal. A One-Pot Synthesis of Bicyclic Imidazoles
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Hua, Duy H.,Zhang, Fengqi,Chen, Jinshan,Robinson, Paul D.
p. 5084 - 5087
(2007/10/02)
Synthesis and pharmacological activity of new heterocyclic compounds: imidazole and triazole polycondensated derivatives
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Maffrand,Frehel,Eloy,et al.
p. 528 - 532
(2007/10/05)
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