Synthesis of 2-hydroxytetrahydrofurans by Wacker-type oxidation of 1,1-disubstituted alkenes
1,1-Disubstituted alkenes feature high steric hindrance, which renders their Wacker-type oxidation difficult. We demonstrate the stereoselective synthesis of 2-hydroxytetrahydrofurans via the Wacker-type oxidation of 3-methyl-3-buten-1-ols by using a PdCl
MnO2-promoted carboesterification of alkenes with anhydrides: A facile approach to γ-lactones
An efficient carboesterification of alkenes with anhydrides promoted by MnO2 has been developed to afford functionalized γ-lactones in good to excellent yields. This method shows a broad substrate scope and provides a valuable and convenient synthetic tool for constructing γ-lactones.
Stereoselectivity of the α-Sulfenylation of 4-Phenylbutyrolactone. Configurational and Conformational Analyses by 1H NMR Spectroscopy
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Flores-Parra, Angelina,Gutierrez-Avella, Dora M.,Guzman-Vazquez, Ysbrain J.,Ariza-Castolo, Armando,Contreras, Rosalinda
p. 6067 - 6071
(2007/10/02)
Reductive Coupling of Ketones or Aldehydes with Electron-deficient Alkenes Promoted by Samarium Di-iodide
Samarium di-iodide is an efficient reagent for the reductive coupling of ketones or aldehydes and electron-deficient alkenes, whereby γ-lactones can be prepared in good yields from ethyl acrylate.