- The Suzuki–Miyaura Cross-Coupling as the Key Step in the Synthesis of 2-Aminobiphenyls and 2,2'-Diaminobiphenyls: Application in the Synthesis of Schiff Base Complexes of Zn
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2-Nitrophenylboronic acids serve as interesting starting materials for the construction of biphenyl- and terphenyl-based amines if subjected to the Suzuki–Miyaura reaction. Unfortunately, these boronic acids suffer from low reactivity in Suzuki reactions, alongside their low stability in the presence of Pd. Herein, a general method for the construction of 2-nitro-substituted bi- and terphenyls is presented, with special emphasis on the synthesis of 2-amino-2'-nitrobi- and terphenyls. Comparisons are made with other boronic acids that have some of the aforementioned issues. Finally, the application of the obtained 2-amino-2'-nitrobi- and terphenyls as starting materials for the synthesis of bi- and terphenyl based di- and triamines is encountered for, with emphasis on the use of these amines as precursors for Schiff base ligands. In addition, the synthesis of some Zn complexes of these ligands is presented.
- Hylland, Knut Tormodss?nn,?ien-?degaard, Sigurd,Tilset, Mats
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supporting information
p. 4208 - 4226
(2020/07/06)
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- Synthesis of Polyfunctionalized Biphenyls as Intermediates for a New Class of Liquid Crystals
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A series of hexa- and octasubstituted biphenyls containing halogen, amino, nitro, and propylthio substituents were prepared by metal-mediated convergent synthesis from halobenzene precursors. The Pd-assisted C-C coupling methods were ineffective in the fo
- Manka, Jason T.,Guo, Fengli,Huang, Jianping,Yin, Huiyong,Farrar, John M.,Sienkowska, Monika,Benin, Vladimir,Kaszynski, Piotr
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p. 9574 - 9588
(2007/10/03)
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- Poly-iodinated compounds, process for their preparation, contrast medium containing them
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The invention relates to novel poly-iodinated compounds of general formula: STR1 in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10, identical or different, are selected from an iodine atom, a group of formula STR2 provided that at least two of the R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 groups represent an iodine atom, utilizable in contrast media for radiography. The invention also relates to a process for the preparation of these compounds as well as a contrast medium containing them.
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