- Ligandless Nickel-Catalyzed Ortho-Selective Directed Trifluoromethylthiolation of Aryl Chlorides and Bromides Using AgSCF3
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A mild protocol for Ni-catalyzed trifluoromethylthiolation of aryl chlorides and bromides is described herein. The method utilizes AgSCF3 as an easily accessible nucleophilic trifluoromethylthiolating reagent and does not require any ligands or additives. Ortho-selectivity is achieved using a variety of directing groups such as imines, pyridines, and oxazolines for 24 examples in up to 95% yield.
- Nguyen, Tin,Chiu, Weiling,Wang, Xinying,Sattler, Madeleine O.,Love, Jennifer A.
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supporting information
p. 5492 - 5495
(2016/11/17)
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- Copper-catalyzed trifluoromethylthiolation of aryl halides with diverse directing groups
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The expansion of cross-coupling components in Cu-catalyzed C-X bond forming reactions have received much attention recently. A novel Cu-catalyzed trifluoromethylthiolation of aryl bromides and iodides with the assistance of versatile directing groups such as pyridyl, methyl ester, amide, imine and oxime was reported. CuBr was used as the catalyst, and 1,10-phenanthroline as the ligand. By changing the solvent from acetonitrile to DMF, the coupling process could even take place at room temperature.
- Xu, Jiabin,Mu, Xin,Chen, Pinhong,Ye, Jinxing,Liu, Guosheng
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supporting information
p. 3942 - 3945
(2014/08/18)
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