A straightforward synthesis of enantiopure (1S,2R)-ephenamine
An enantioselective six-step synthesis of (1S,2R)-ephenamine starting from readily available chiral amino acid is disclosed presenting 26% overall yield and high optical purity. The use of chiral phenylglycine as starting material was also studied and did
Martins, José E. D.,Velho, Arthur C. C.
p. 2462 - 2469
(2020/11/18)
Synthesis of potential impurities of cefalexin and cefradine
The synthesis of some impurities of the cephalosporin antibiotics cefalexin and cefradine is described. These impurities which may be present in commercial samples are formed during the semi-synthetic preparation of these antibiotics or upon their degradation. The preparation of these compounds enables the validation of selective quantitative analytical methods, such as column liquid chromatography and thin layer chromatography.