- Interaction of difluoromethylene phosphobetaine with heteroatom-centered electrophiles
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A series of difluorinated phosphonium salts were obtained by reaction of difluoromethylene phosphobetaine with halogenating reagents, as well as arylsulfenyl and arylselenyl chlorides. The reaction proceeds via decarboxylation of the phosphobetaine followed by trapping of the difluorinated phosphorus ylide by heteroatom-centered electrophiles. The crystal structures of the phosphonium salts were studied by X-ray diffraction analysis. For the salt containing the CF2I group and iodide counterion, the I?I interaction was identified in the solid state. The nature of this halogen bond was evaluated by quantum chemical calculations.
- Trifonov, Alexey L.,Panferova, Liubov I.,Levin, Vitalij V.,Volodin, Alexander D.,Korlyukov, Alexander A.,Dilman, Alexander D.
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- Alternative synthetic routes to hydrofluoroolefins
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A series of hydrofluoroolefins with -CF=CH2, -CH=CHF and -CH=CF2 groups were designed and prepared via various synthetic routes, including HX or BrF elimination, Wittig-type olefination or fluorination using SF4.
- Yagupolskii, Yu. L.,Pavlenko,Shelyazhenko,Filatov,Kremlev,Mushta,Gerus,Peng, Sheng,Petrov,Nappa, Mario
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p. 134 - 141
(2015/11/10)
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- Substituted imidazo[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives
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The present invention is concerned with substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of the formula I wherein R1 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkox
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Page/Page column 22
(2010/11/08)
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- synthesis and crystal structure of bromodifluoromethyl-triphenylphosphonium bromide, [(C6H5)3PCF2Br]+ Br-
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Difluorobromomethyl-triphenylphosphonium bromide [(C6H5)3PCF2Br]+ Br- (1) has been prepared by the reaction of triphenylphosphine with dibromodifluoro-methane in acetonitrile or methylene c
- Bender,Wulff-Molder,Vogt,Ritschl,Meisel
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p. 167 - 170
(2007/10/03)
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- Substituent Effects on the Structure of Spiropentane
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In order to investigate the influence of substituents on the bond lengths of the spiropentane framework, the molecular structures of the spiropentane derivates 1-7 have been determined by X-ray analysis.The ? acceptor (CO, CO2R, Ph) shorten the distal bon
- Irngartinger, Hermann,Gries, Stefan,Klaus, Philip,Gleiter, Rolf
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p. 2503 - 2512
(2007/10/02)
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- gem-Difluorocyclopropanes: An improved method for their preparation
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By treatment with dibromodifluoromethane and triphenylphosphine, four unfunctionalized olefins, four enethers and one bis-enether were converted to the gem-difluorocyclopropanes 1-9. The yields were considerably increased and isomerizations at the double bonds were avoided if the reactions were carried out in the presence of a macrocyclic polyether such as "18-crown-6" and if, in addition, the reagents were employed in moderate excess.
- Bessard, Yves,Mueller, Ulrich,Schlosser, Manfred
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p. 5213 - 5221
(2007/10/02)
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- REACTION OF DIFLUOROCARBENE WITH SMALL BICYCLIC MOLECULES
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Difluorocarbene reacts with 1,2,2-trimethylbicyclobutane to give the product of two bond cleavage, 1,1-difluoro-3,3,4-trimethyl-1,4-pentadiene in 3percent yield.Bicyclopentane is even less reactive, yielding 1,1-difluorohexa-1,5-diene in ca. 0.5percent yield.Bicyclohexane does not react with difluorocarbene.Theoretical descriptions of these reactions are discussed.
- Jackson, E. James,Misslitz, Ulf,Jones, Maitland,Meijere, A. de
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p. 653 - 662
(2007/10/02)
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- PREPARATION AND SYNTHETIC UTILITY OF FLUORINATED PHOSPHONIUM SALTS, BISPHOSPHONIUM SALTS AND PHOSPHORANIUM SALTS
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The reaction of tertiary phosphines with fluorohalomethanes provides a rapid and high yield synthesis of various types of fluorinated phosphonium salts, bis-phosphonium salts and phosphoranium salts.These salts are useful precursors to fluorine-containing
- Burton, Donald J.
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p. 339 - 358
(2007/10/02)
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- Metal Dehalogenation Route To Reactive Fluoroolefins
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Metal dehalogenation of bromodifluoromethyltriphenylphosphonium bromide with Cd, Zn, or Hg provides a practical route to fluoroolefins that contain an allylic halogen or a pentafluorophenyl group.No SN2' or ring substituted products are observed.
- Burton, D. J.,Kesling, H. S.,Naae, D. G.
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p. 293 - 298
(2007/10/02)
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- Reaction of Diphenyl- and Difluorocarbenes with 3,7-Dimethylenebicyclononane
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Both difluorocarbene and diphenylcarbene add to 3,7-dimethylenebicyclononane to give mono- and diadducts.Products of abstraction-recombination are produced from diphenylcarbene, but neither carbene gives products of conjugate addition.
- Krasutsky, Pavel A.,Jones, Maitland
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p. 2425 - 2429
(2007/10/02)
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