- 4-thio substituted quinoline and naphthyridine compounds
-
The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.
- -
-
Page/Page column 18
(2009/04/24)
-
- 4-THIO SUBSTITUTED QUINOLINE AND NAPHTHYRIDINE COMPOUNDS
-
The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.
- -
-
Page/Page column 43
(2008/06/13)
-
- Synthesis of SMP-797: A new potent ACAT inhibitor
-
A potent ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor SMP-797 was effectively synthesized by the urea formation of 3-amino-4-aryl-1,8- naphthyridin-2(1H)-one and 4-amino-2,6-diisopropylamine. The synthesis of the former compound involved the Suzuki coupling reaction as a key step, and the latter was prepared by the 4-selective nitration of 2,6-diisopropylaniline using 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone.
- Ban, Hitoshi,Muraoka, Masami,Ohashi, Naohito
-
p. 10081 - 10092
(2007/10/03)
-
- A convenient synthesis of 4-aryl-1,8-naphthyridin-2(1H)-ones by the Suzuki coupling
-
4-Halo-1,8-naphthyridin-2(1H)-ones readily available from 2-chloronicotinic acid were subjected to the Suzuki coupling reaction with arylboronic acids to give a diversity of 4-aryl-1,8-naphthyridin-2(1H)-ones.
- Ban, Hitoshi,Muraoka, Masami,Ohashi, Naohito
-
p. 6021 - 6023
(2007/10/03)
-