TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS
The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.
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Paragraph 00188
(2021/10/30)
New Monodisperse Magnetic Polymer Microspheres Biofunctionalized for Enzyme Catalysis and Bioaffinity Separations
Magnetic macroporous PGMA and PHEMA microspheres containing carboxyl groups are synthesized by multi-step swelling and polymerization followed by precipitation of iron oxide inside the pores. The microspheres are characterized by SEM, IR spectroscopy, AAS
Templating a polymer-scaffolded dynamic combinatorial library
A water soluble polymer-scaffolded dynamic combinatorial library whose members can interconvert through acylhydrazone exchange was prepared and shown to re-equilibrate in the presence of macromolecular templates.
Mahon, Clare S.,Jackson, Alexander W.,Murray, Benjamin S.,Fulton, David A.
supporting information; experimental part
p. 7209 - 7211
(2011/09/12)
Supramolecular dendrimers: Unusual mesophases of ionic liquid crystals derived from protonation of DAB dendrimers with facial amphiphilic carboxylic acids
Supramolecular liquid crystalline (LC) dendrimers were prepared by self-assembly of first to fifth generation amino terminated DAB dendrimers with facial amphiphilic carboxylic acids. These carboxylic acids are composed of three distinct incompatible segm
Cook, Andrew G.,Baumeister, Ute,Tschierske, Carsten
p. 1708 - 1721
(2008/12/20)
PYRROLOPYRIDAZINE DERIVATIVES
The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
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Page 250
(2008/06/13)
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