- Trisbenzimidazoles useful as topoisomerase I inhibitors
-
The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: STR1 wherein Ar is (C6 -C12)aryl or (5- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with (C1 -C4)alkyl; X is H, CN, CHO, OH, acetyl, CF3, O(C1 -C4)alkyl, NO2, NH2, halogen or halo-(C1 -C4)alkyl; each Y is individually H, (C1 -C4)alkyl or aralkyl; Y' is H or (C1 -C4)alkyl; n is 0 or 1; and each Z is individually H, (C1 -C4)alkyl, halogen or halo(C1 -C4)alkyl; or a pharmaceutically acceptable salt therein.
- -
-
-
- Terbenzimidazoles useful as antifungal agents
-
The present invention provides a method of treatment of fungal infection with an antifungal topoisomerase I inhibitor of the formula: STR1 wherein Ar is (C6 -C12)aryl, a (5- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with H, (C1 -C4)alkyl or benzyl; or benzo; X is H, CN, CHO, OH, acetyl, CF3, O(C1 -C4)alkyl, NO2, NH2, halogen or halo-(C1 -C4)alkyl; each Y is individually H, (C1 -C4)alkyl or aralkyl; Y' is H or (C1 -C4)alkyl; n is 0 or 1; and each Z is individually H, (C1 -C4)alkyl, halogen or halo(C1 -C4)alkyl; or a pharmaceutically acceptable salt thereof.
- -
-
-