- 1,4-DICARBONYL-PIPERIDYL DERIVATIVES
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Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
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Page/Page column 53
(2017/07/01)
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- Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: Rhodium-catalyzed multicomponent synthesis of N-heterobicyclic enones
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Aminocyclopropanes equipped with suitable N-directing groups undergo efficient and regioselective Rh-catalyzed carbonylative C-C bond activation. Trapping of the resultant metallacycles with tethered alkynes provides an atom-economic entry to diverse N-heterobicyclic enones. These studies provide a blueprint for myriad N-heterocyclic methodologies.
- Shaw, Megan H.,Melikhova, Ekaterina Y.,Kloer, Daniel P.,Whittingham, William G.,Bower, John F.
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supporting information
p. 4992 - 4995
(2013/05/22)
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