Design and synthesis of an Fmoc-SPPS-compatible amino acid building block mimicking the transition state of phosphohistidine phosphatase
The synthesis of a sulfonamide-based transition-state (TS) analogue of enzymatic phosphohistidine dephosphorylation as an amino acid building block is presented, together with the proof-of-concept of its incorporation into peptides. Key features include f
Eerland, Martijn F.,Hedberg, Christian
experimental part
p. 2047 - 2052
(2012/04/23)
THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE
Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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Page/Page column 97
(2010/11/03)
4-Imidazolylsulfonylimidazoles
4-Imidazolylsulfonamides and 4-imidazolylsulfonylimidazoles are useful as plasticizers. These compounds are obtained by reaction of 4-imidazolesulfonyl chloride with an amine, such as imidazole. 4-Imidazolesulfonyl chloride itself is useful as a reactant
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(2008/06/13)
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