Efficient syntheses of 2-fluoroalkylbenzimidazoles and -benzothiazoles
We report an efficient one-step route to 2-fluoroalkylbenzimidazoles and -benzothiazoles via the condensation of fluorinated carboxylic acids and aromatic diamines or aminothiophenols. Additionally, we describe the syntheses of fluoroalkyl-azabenzimidazoles, -purines, and -imidazolopyrazines. This method is high-yielding with broad scope and is operationally simple with potential application to parallel synthesis.
René, Olivier,Souverneva, Alexandra,Magnuson, Steven R.,Fauber, Benjamin P.
supporting information
p. 201 - 204
(2013/02/22)
1H imidazo[4,5 b]pyrazines. I. 2 Alkyl derivatives (1)
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Tong
p. 1127 - 1131
(2007/10/07)
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