Syntheses de β-sultames (thiazetidines-1,2 dioxyde-1,1)
β-sultams (1,2-thiazetidine-1,1-dioxides) are easily prepared by 1-halogensulphonyl-2-aminoalkane cyclisation. Two processes based upon this principle have permitted the preparation of many variously N and C-substituted β-sultams. 1) In the first method 1-chlorosulphonyl-2-aminoalkane hydrochlorides, prepared from taurines or β-aminothiols, cyclised in the presence of base. 2) The second process involves the spontaneous cyclisation of 1-fluorosulphonyl-2-aminoalkanes prepared Michael addition of primary amines to 1-fluorosulphonylethene.
Champseix, A.,Chanet, J.,Etienne, A.,Berre, A. Lemasson, J. C.,Napierala, C.,Vessiere, R.
p. 463 - 472
(2007/10/02)
SYNTHESIS AND PROPERTIES OF β-SULTAMS
β-Sultames substituted in 2- and 3-position including bicyclic β-sultams were prepared and some of their reactions are reported.
Synthesis and radiopharmacological study of unsaturated derivatives of cysteamine
Synthesis of many unsaturated compounds derivated from cysteamine has been carried out in the three series : β-aminothioethers, β-aminothiols and thiazolidines. These products are more or less toxic, compared to corresponding saturated derivates. They generally have a higher radioprotective activity. The three most effective have a dose reduction factor equivalent to that of cysteamine, two of them having a lower toxicity.
Mesnard,Miginiac,Fatome,et al.
p. 247 - 252
(2007/10/02)
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