Synthesis and biological evaluation of novel rhodanine-based structures with antiviral activity towards HHV-6 virus
An increased awareness of diseases associated with Human herpesvirus 6 (HHV-6) infection or reactivation has resulted in a growing interest in the evaluation of the best treatment options available for the clinical management of HHV-6 disease. However, no
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase
We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyro
Xie, Yuli,Liu, Yidong,Gong, Gangli,Rinderspacher, Alison,Deng, Shi-Xian,Smith, Deborah H.,Toebben, Udo,Tzilianos, Effie,Branden, Lars,Vidovic, Dusica,Chung, Caty,Schuerer, Stephan,Tautz, Lutz,Landry, Donald W.
p. 2840 - 2844
(2008/12/21)
Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors
We report on the design, synthesis, and evaluation of a series of furanyl-salicyl-nitroxide derivatives as effective chemical probes for second-site screening against phosphotyrosine phosphatases (PTPs) using NMR-based techniques. The compounds have been
Vazquez, Jesus,Tautz, Lutz,Ryan, Jennifer J.,Vuori, Kristiina,Mustelin, Tomas,Pellecchia, Maurizio
p. 2137 - 2143
(2008/02/01)
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