Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists
A novel series of pyrazolo[1,5-a]pyrimidine derivatives was synthesized and evaluated as NPY Y1R antagonists. High binding affinity and selectivity were achieved with C3 trisubstituted aryl groups and C7 substituted 2-(tetrahydro-2H-pyran-4-ylamino)ethyla
Griffith, David A.,Hargrove, Diane M.,Maurer, Tristan S.,Blum, Charles A.,De Lombaert, Stéphane,Inthavongsay, John K.,Klade, Lee E.,MacK, Christine M.,Rose, Colin R.,Sanders, Martin J.,Carpino, Philip A.
scheme or table
p. 2641 - 2645
(2011/06/20)
Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same
The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrat
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(2008/06/13)
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