- Synthesis method of 3-amino-4-chloro-N-(3-chloro-2-methylphenyl)benzamide
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The invention discloses a synthesis method of 3-amino-5-chloro-N,3-dimethyl benzamide, and belongs to the organic chemical synthesis technical field. The synthesis method comprises the steps: 3-nitro-4-chlorobenzoic acid is used as a raw material, N,N'-diisopropyl carbodiimide is used as a condensing agent, 1-hydroxybenzotriazole is used as a condensation activator, firstly, 3-nitro-4-chlorobenzoic acid and N,N'-diisopropyl carbodiimide are subjected to an addition reaction, an addition product is not stable and is converted to a corresponding ester under the action of 1-hydroxybenzotriazole, then the corresponding ester is subjected to a reaction with 3-chloro-2-methylaniline to obtain 3-nitro-4-chloro-N-(3-chloro-2-methylphenyl)benzamide, next the 3-nitro-4-chloro-N-(3-chloro-2-methylphenyl)benzamide is reduced into 3-amino-4-chloro-N-(3-chloro-2-methylphenyl)benzamide under the action of zinc and sodium hydroxide. The synthesis method has the advantages of simple operation, less steps, and short production cycle, and the synthesis yield is increased significantly and is increased to 95% or more.
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Paragraph 0005; 0014; 0015
(2016/12/22)
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- One step diazotization coupling process
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A process for producing metal-free azo pigments in purely organic liquid or aqueous/organic liquid containing at most 10% of water calculated on the total weight of the suspension is described. In this one-step process, a suitable aromatic amine is diazotized without isolation of the obtained diazo compound and coupled with a coupling component. Both reactions are carried out in purely or essentially organic medium. The latter consists essentially of such amount of an organic liquid that a substantial portion either of the diazo component or of the coupling component or of both these reactants remain undissolved. Both reactants must be free from sulphonic acid groups. If the resulting azo pigment contains carboxylic acid groups, these can be subsequently converted to the corresponding amido or ester groups.
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