- Kinetics of the brominated alkyl radical (CHBr2, CH 3CHBr) reactions with NO2 in the temperature range 250-480 K
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The gas-phase kinetics of CHBr2 + NO2 and CH 3CHBr + NO2 reactions have been studied in direct time resolved measurements using a tubular flow reactor coupled to a photoionization mass spectrometer. The radicals were generated by pulsed laser photolysis of bromoform and 1,1-dibromoethane at 248 nm. The subsequent decays of the radical concentrations were monitored as a function of [NO2] under pseudo-first-order conditions. The rate coefficients of both reactions are independent of bath gas (He) pressure and display negative temperature dependence under the conditions of 2-6 Torr pressure (He) and 250-480 K. The obtained bimolecular rate coefficients are k(CHBr2 + NO2) = (9.8 ± 0.4) × 10-12 (T/300 K) -1.65 ± 0.18 cm3 s-1 (288-483 K) and k(CH3CHBr + NO2) = (2.27 ± 0.06) × 10 -11 (T/300 K)-1.28 ± 0.11 cm3 s -1 (250-483 K), with the uncertainties given as one standard error. Estimated overall uncertainties in the measured bimolecular reaction rate coefficients are ±25%. The reaction products identified were CBr 2O for the CHBr2 + NO2 reaction and CHBrO and CH3CHO with minor amounts of CH3 for the CH 3CHBr + NO2 reaction, respectively. 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 767-777, 2012 Copyright
- Rissanen, Matti P.,Eskola, Arkke J.,Timonen, Raimo S.
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- Method of treating addiction or dependence using a ligand for a monoamine receptor or transporter
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One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a therapuetically effective amount of a heterocyclic compound, e.g., a 3-substituted piperidine. In a preferred embodiment, the method of the present invention treats cocaine addiction or methamphetamine addiction.
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- Ligands for monoamine receptors and transporters, and methods of use thereof
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One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.
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- Sulfonamides useful as carbonic anhydrase inhibitors
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Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
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- Thiophene sulfonamides useful as carbonic anhydrase inhibitors
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Thiophene sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
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- MOLECULAR STRUCTURE OF CARBONYL BROMIDE AS STUDIED BY GAS ELECTRON DIFFRACTION
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The molecular structure of COBr2, has been determined as follows by an analysis of electron diffraction intensity: rg(C=O) = 1.178 +/- 0.009 Angstroem, rg(C-Br) = 1.923 +/- 0.005 Angstroem and Θα0(Br-C-Br) = 112.3 +/- 0.4 deg.The uncertainties represent estimated limits of error.The observed systematic trends in the bond lengths and bond angles in carbonyl and thiocarbonyl halides are discussed.
- Nakata, Munetaka,Fukuyama, Tsutomu,Wilkins, C. J.,Kuchitsu. Kozo
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p. 195 - 202
(2007/10/02)
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- Novel steroidspirooxazolidines and process for their preparation
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The invention relates to novel spirooxazolidines represented by the formula I STR1 wherein R1 is alkyl having from 1 to 4 carbon atoms; R2 is hydrogen, alkyl having from 1 to 4 carbon atoms, alkenyl having from 1 to 4 carbon atoms, or dialkylphosphinoxymethyl having in the alkyl moiety from 1 to 3 carbon atoms each; Z is one of the groups represented by the formulae III to XIV as subsequently defined therein.
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