- A synthesis of nikkomycin Z: Improved synthesis and protection of the pyridyl γ-hydroxy-α-aminobutanoic acid component
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The first synthesis of nikkomycin Z is described. An improvement of the isoxazoline-based methodology and an effective method for protection of 1b were devised. The application of oxalyditriazole (23) for peptide coupling proved most effective in completing the synthesis. A new and efficient synthesis of the prerequisite pyridyl E-olefin (5) is also described.
- Saksena,Lovey,Girijavallabhan,Guzik,Ganguly
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p. 3267 - 3270
(2007/10/02)
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- Antibiotics, a process for their preparation and their use as plant protection agents
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A method of combating arthropods, comprising applying to the arthropods, or to a habitat infested therewith an arthropodicidally effective amount of an antibiotic which (a) is colorless, very readily soluble in water and in pyridine but insoluble in other customary organic solvents, gives a positive reaction with ninhydrin, sodium metaperiodate/benzidine and potassium permanganate and gives a yellow coloration with iron (III) chloride, (b) has the UV and IR spectra substantially as shown in FIGS. 1 and 2, (c) on chemical degradation yields uracil, an amino-hexuronic acid and an amino-acid containing a pyridine ring, (d) on paper electrophoresis proves to be an amphoteric substance and has an isolectric point at about pH 6 and (e) consists of the elements carbon, hydrogen, oxygen and nitrogen, or one or more active components of the antibiotic mixture, the active agent being applied alone or in admixture with a diluent or carrier. The antibiotic is known as Nikkomycin which is apparently a mixture of components of the formula STR1 in which R1 is STR2 and R2 is hydrogen, STR3
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