- Anti-HIV agent
-
The invention relates to an anti-HIV agent comprising, as an active ingredient, at least one porphyrin derivative selected from the following derivatives (A) and (B): (A) porphyrins modified with a compound selected from carbodiimides, alkylenediamines and alcohols; and (B) complexes of a plasma protein or a chemically modified plasma protein and a porphyrin which may have been modified with a compound selected from carbodiimides, alkylenediamines and alcohols. This anti-HIV agent is excellent in killing effect on HIV-infected cells, inhibitory effect on cytopathy due to HIV infection and HIV-replication inhibiting effect, and high in safety.
- -
-
-
- Preparation of Carbodiimides from Phosphoramidates
-
ω-Dialkylaminoalkylphosphoramidates are converted to ω-dialkylaminoalkyl(alkyl)carbodiimides in good yield in a two-phase system by reaction with isocyanates.
- Jaszay, Zsuzsa M.,Petnehazy, Imre,Toeke, Laszlo,Szajani, Bela
-
p. 397 - 399
(2007/10/02)
-
- Preparation of Carbodiimides Using Phase-Transfer Catalysis
-
A new method is described for the preparation of carbodiimides by dehydration of ureas with arenesulfonyl chlorides under solid-liquid phase-transfer catalytic (PTC) conditions using solid potassium carbonate as a base and a lipophilic quaternary ammonium salt as a catalyst.The method is generally applicable for the synthesis of disubstituted carbodiimides, but is especially useful for unsymmetrically substituted carbodiimides.The basic carbodiimides prepared were identified in the form of the more stable, crystalline quaternary salts.
- Jaszay, Zsuzsa M.,Petnehazy, Imre,Toeke, Laszlo,Szajani, Bela
-
p. 520 - 523
(2007/10/02)
-