- JNK inhibitor as well as pharmaceutical composition and application thereof
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The invention provides a compound represented by a formula (I), racemates, stereoisomers, tautomers, isotope markers, solvates, polymorphic substances, nitrogen oxides, or pharmaceutically acceptablesalts thereof, and application as a JNK inhibitor. The invention also provides a preparation method of the compound shown in the formula (I), a pharmaceutical composition containing the compound shownin the formula (I), and application of the compound shown in the formula (I) to preparation of a medicine, and the medicine is used for treating diseases which can be treated by inhibiting the activity of JNK.
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Paragraph 0381-0385
(2021/03/31)
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- Substituted sulphoximines as Tie2 inhibitors and salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same and uses of the same
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The invention relates to substituted sulphoximines according to the general formula (I): in which A, E, G, X, R1, R2, R3, R4, R5, R6, R7, R8, m, p, q, are given in the
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Page/Page column 36
(2008/06/13)
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- NOVEL HETARYL-PHENYLENEDIAMINE-PYRIMIDINES AS PROTEIN KINASE INHIBITORS
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The invention relates to novel hetaryl-phenylenediamine-pyrimidines and to their structurally related oxygen and sulphur analogues of the general formula I, processes for their preparation, and their use as medicaments.
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Page/Page column 8
(2008/12/07)
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- SULFOXIMINE-SUBSTITUTED PYRIMIDINES , THEIR PREPARATION AND USE AS DRUGS
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The invention relates to sulfoximine-substituted pyrimidines of the general Formula (I) processes for the preparation thereof and their use as kinase inhibitors for treating for example cancer or inflammation.
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Page/Page column 252-253
(2010/11/27)
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- Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs
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The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs.
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Page/Page column 109
(2010/11/28)
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- Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors
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The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABAB receptors is presented.
- Guery, Sebastien,Floersheim, Philipp,Kaupmann, Klemens,Froestl, Wolfgang
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p. 6206 - 6211
(2008/04/03)
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