Solid-Phase Synthesis of the Peptaibol Alamethicin U-22324 by Using a Double-Linker Strategy
The facile Fmoc (Fluorenylmethoxycarbonyl) solid-phase synthesis of the α-helical-channel-forming peptaibol alamethicin U-22324 is described. A late-stage reduction by using a new double-linker method was used to introduce the C-terminal alcohol. Furthermore, we also report the synthesis of an alamethicin analogue with a C-terminal carboxylic acid.
Siow, Andrew,Hung, Kuo-Yuan,Harris, Paul W. R.,Brimble, Margaret A.
A SOLID-SUPPORTED HYDROXY AMINO ACID AND A SOLID-SUPPORTED AMINO ALCOHOL
There is provided a solid-supported hydroxy amino acid or a solid-supported amino alcohol of Formula (I) as defined herein. There is further provided a method of making the solid-supported hydroxy amino acid or the solid-supported amino alcohol. There is further provided a method of making a peptide alcohol by using the solid-supported hydroxy amino acid or the solid-supported amino alcohol. There is also provided a peptide alcohol, obtained by using the solid-supported hydroxy amino acid or the solid-supported amino alcohol. There is also provided a stapled peptide alcohol and medical uses thereof.
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Paragraph 00198
(2020/02/23)
SOLUTION PHASE SYNTHESIS OF ALAMETHICIN I
The total synthesis of alamethicin I by solution phase methods is reported.
Nagaraj, R.,Balaram, P.
p. 1263 - 1270
(2007/10/02)
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