- A copper(II)-thioamide combination as a robust heterogeneous catalytic system for green synthesis of 1,4-disubstituted-1,2,3-triazoles under click conditions
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An efficient and practical synthesis of 1,4-disubstituted-1,2,3-triazoles under click conditions using a copper(ii)-thioamide combination as an efficient heterogeneous catalyst is disclosed. Mild reaction conditions and high yields make this method an attractive option for the preparation of triazole derivatives. The key to this procedure was the generation of Cu(I) required for the azide-alkyne cycloaddition, which was achieved by in situ reduction of Cu(II) using thiobenzanilide as reduction agent and ligand.
- Mirjafary, Zohreh,Ahmadi, Leila,Moradi, Masomeh,Saeidian, Hamid
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p. 78038 - 78046
(2015/09/28)
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- Acid-catalysed Rearrangement of Bis-5,6-Dihydro-4H-1,3-thiazin-2-yl and Other Disulphides and Related Reactions
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Some dithiocarbamates, thiocarbamates, and thiourea derivatives have been oxidised to the disulphides 1X(R2N=)C>2S2 with iodine.In the presence of trifluoroacetic acid, these lost sulphur giving the thiocarbonyl derivatives R1X(R2N=)C-N(R2)CSR1 (R1, R2, X =3, S; 2, S; Me, Me, S; Et, PhCH2, O; 5α-cholestan-3β-yl, Et, O; and Me, Ph, NMe).These rearrangements were most plausibly intramolecular, but proceeded by varying extents of intermolecular scrambling.
- Barrett, Anthony G. M.,Barton, Derek H. R.,Colle, Roberto
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p. 665 - 671
(2007/10/02)
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