- Piperacillin sodium compound containing half water
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The invention discloses a piperacillin sodium compound containing half water and a preparation method thereof. Each mole of piperacillin sodium contains a half mole of water. First, ampicillin trihydrate is reacted with 4-ethyl-2,3-dioxypiperazine formyl chloride to form piperacillin acid, then piperacillin acid is reacted with sodium acetate in a mixed solution of acetone and water, isopropanol is added dropwise, and crystallization, filtration and drying are conducted to obtain the piperacillin sodium compound containing half water. The piperacillin sodium compound containing half water hashigh fluidity, low hygroscopicity and impurity content, high thermodynamic stability and a wider application prospect.
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Paragraph 0029; 0032-0035; 0037; 0040-0043; 0045-0048
(2019/01/23)
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- A process for preparing an injectable sterile pharmaceutical formulation containing at least piperacillin sodium and tazobactam sodium as active principles
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Mixtures of at least two active principles, e.g. of piperacillin and tazobactam of which at least one is the sodium salt, are precipitated from an organic solution containing the same active principles in salified or non-salified acid form.
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Page/Page column 2-3
(2008/06/13)
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- Process for the preparation of 6-[D(-)alpha-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alpha-phenylacetamido]-penicillanic acid and intermediates useful in this process
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The 6-[D(-)-alpha(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alphaphenylacetamido]penicillanic acid and the salts thereof are prepared by synthetizing the novel intermediates, thioesters of D(-)-alpha-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alpha-phenylacetic acid, with mercaptoheterocycles and by converting them into the desired compound by reaction with 6-amino-penicillanic acid.
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