Total synthesis of cis and trans-hydroxyglimepiride: Active metabolite of glimepiride
Syntheses of trans-hydroxyglimepiride 2b, a human metabolite of the blood glucose lowering agent glimepiride 1 and its corresponding cis-stereoisomer 2a, are described.
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3-ethyl-2,5-dihydro-N-[2-[4-[[[[[4-[(4-methoxyphenyl)methoxy]cyclohexyl]
amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-4-methyl-2-oxo-