- Copper-Catalyzed Three-Component Domino Cyclization for the Synthesis of 4-Aryl-5-(arythio)-2-(trifluoromethyl)oxazoles
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A copper-catalyzed oxidative cyclization of oxime, arylthiol, and trifluoroacetic anhydride for the construction of trisubstituted oxazoles has been developed. This transformation combines N-O bond cleavage, C-H functionalization, and intramolecular annulation, providing a practical protocol for the introduction of a trifluoromethyl (-CF3) group at oxazole rings.
- Xiao, Fuhong,Yuan, Shanshan,Huang, Huawen,Zhang, Feng,Deng, Guo-Jun
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supporting information
p. 8533 - 8536
(2019/10/17)
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- Synthesis and structural characterization of four novel bisoxime-type compounds based on 2,2'-(Ethylenedioxy)bisbenzaldehyde
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A series of bisoxime compound have been synthesized by the reaction of 2,2'-(ethyylenedioxy) bisbenzaldehyede with hydroxylamine hydrochloride methoxyamine hydrochloride ethyoxylamine hydrochloride or 3-aminoacetophenone oxime in hot ethanol medium, respe
- Wang, Li,Gao, Su-Xia,Zhang, Yang,Li, Gang,Zhang, Yu-Jie
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p. 6272 - 6274
(2015/02/19)
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- Synthesis of ketoximes via a solvent-assisted and robust mechanochemical pathway
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A versatile and robust mechanochemical route to ketone-oxime conversions has been established for a broad range of ketones via a simple mortar-pestle grinding method. The relative reactivity of aldehydes vs. ketones under these conditions has also been explored, along with an examination of the possible connection between reactivity and electronic substituent effects.
- Aakeroey, Christer B.,Sinha, Abhijeet S.
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p. 8168 - 8171
(2013/09/02)
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- Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
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A novel series of inhibitors for mitogen activated protein kinase-activated protein kinase 2 (MK-2) are reported. These squarate based inhibitors were identified via a high-throughput screen. An MK2 co-structure with the starting ligand was obtained and a structure based approach was followed to optimize potency and selectivity.
- Lovering, Frank,Kirincich, Steve,Wang, Weiheng,Combs, Kerry,Resnick, Lynn,Sabalski, Joan E.,Butera, John,Liu, Julie,Parris, Kevin,Telliez
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experimental part
p. 3342 - 3351
(2009/09/08)
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- Highly effective receptors showing di- vs. monosaccharide preference
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Receptors 1 and 2, incorporating two heterocyclic recognition units as well as oxime- or hydroxymethyl-based hydrogen-bonding sites, were prepared, and their binding properties toward neutral sugars were determined. The design of these receptors was inspi
- Mazik, Monika,Buthe, Arno C.
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scheme or table
p. 1558 - 1568
(2008/10/09)
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- O-ALLYL ETHER AS A NEW PROTECTIVE GROUP FOR OXIMES AND ITS PALLADIUM-CATALYZED DEPROTECTION.
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Oximes are protected by O-allyl ether formation, and their palladium-catalyzed deallylation using triethylammonium formate as a reductant proceeds smoothly in boiling ethanol under mild conditions offering a good protective method for oximes.
- Yamada, Toshiro,Goto, Kuniaki,Mitsuda, Yasuhiro,Tsuji, Jiro
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p. 4557 - 4560
(2007/10/02)
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