- A method for preparing chlorine Shu Long
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The invention discloses a preparation method of clorsulon. The preparation method comprises the steps: carrying out condensation on m-nitrobenzaldehyde with chloroform at a low temperature, then chloridizing, and carrying out elimination, hydrazine hydrate reduction, chlorosulfuric acid sulphonation and ammonification to obtain clorsulon. The use of benzene with relatively high toxicity is avoided, the use of chlorine with relatively large dangerousness is also avoided, the reduction reaction adopts more environmentally-friendly hydrazine hydrate, hydrazine hydrate reduction has less solid waste than iron powder reduction, an excellent catalyst ferric trichloride and an activated carbon carrier are selected, a by-product nitrogen gas has a good protective effect on the product, the product quality is high, the yield is equivalent to the yield reported in literature, the process is simplified, reaction conditions are mild, and the preparation method is environmentally friendly and has good industrial application prospects.
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Paragraph 0026; 0033; 0034
(2017/02/17)
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- 4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide
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The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3- benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.
- Mrozik,Bochis,Eskola,Matzuk,Waksmunski,Olen,Schwartzkopf Jr.,Grodski,Linn,Lusi,Wu,Shunk,Peterson,Milkowski,Hoff,Kulsa,Ostlind,Campbell,Riek,Harmon
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p. 1225 - 1227
(2007/10/06)
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