- INHIBITORS OF GLUCOSE TRANSPORTERS (GLUTS)
-
The present invention relates to 2,6-methanobenzo[g][1]oxacin-4-onecompounds and their analog compounds and pharmaceutically acceptable salts thereof as selective inhibitor of glucose transporters 1 and 3 (GLUTs 1 and 3), to methods of preparing said compounds, and to the use thereof as pharmaceutically active agents, especially for the prophylaxis and/or treatment of metabolic diseases, immunological diseases, autoimmune diseases, inflammation, graft versus host disease, cancer, and metastasis thereof. Furthermore, the present invention is directed to pharmaceutical composition comprising at least one of 2,6-methanobenzo[g][1]oxacin-4-one compounds and their analog compounds.
- -
-
Page/Page column 55-56; 61
(2020/03/29)
-
- Copper(I)-catalyzed hydroalkoxylation/hydrogen-bonding-induced asymmetric hetero-diels-alder cycloaddition cascade: An approach to aromatic spiroketals
-
One thing leads to another: Bis(benzannelated) 5,6-spiroketal skeletons can be constructed by an efficient cascade process involving an unprecedented CuI-catalyzed intramolecular alkyne hydroalkoxylation and an asymmetric hetero-Diels-Alder cyc
- Li, Xin,Xue, Jijun,Huang, Chusheng,Li, Ying
-
supporting information; experimental part
p. 903 - 906
(2012/07/03)
-
- A mild and efficient acetylation of alcohols, phenols and amines with acetic anhydride using La(NO3)3·6H2O as a catalyst under solvent-free conditions
-
A wide variety of alcohols, phenols and amines are efficiently and selectively converted into the corresponding acetates by treatment with acetic anhydride in the presence of catalytic amounts of La(NO3)3·6H2O under solvent-free conditions at room temperature. The method is compatible with acid sensitive hydroxyl protecting groups such as TBDMS, THP, OBz, OBn, Boc and some isopropylidenes and offers excellent yields of the mono acetates of 1,3-, 1,4- and 1,5-diols.
- Reddy, T. Srikanth,Narasimhulu,Suryakiran,Mahesh, K. Chinni,Ashalatha,Venkateswarlu
-
p. 6825 - 6829
(2007/10/03)
-
- A facile and efficient ZrCl4 catalyzed conversion of aldehydes to geminal-diacetates and dipivalates and their cleavage
-
A novel, mild and efficient method has been developed for the preparation of geminal-diacetates and dipivalates in high yields through a reaction of aldehydes with acetic anhydride or pivalic anhydride using Zirconium (IV) chloride as a catalyst under solvent free conditions. Regeneration of aldehydes from the acylals was also achieved using the same catalyst in CH3OH.
- Smitha,Reddy, Ch. Sanjeeva
-
p. 9571 - 9576
(2007/10/03)
-