- Total synthesis of pikromycin
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The total synthesis of pikromycin (6), the first isolated macrolide antibiotic, was achieved. The target macrolide was retrosynthetically divided into two parts, pikronolide (6a) (aglycon) and d-desosamine. The aglycon was synthesized using key reactions
- Oh, Hong-Se,Kang, Han-Young
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experimental part
p. 1125 - 1130
(2012/03/22)
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- Macrolide biosynthesis: A single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae
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The final step in the biosynthesis of methymycin, neomethymycin, and picromycin is an hydroxylation, shown to be carded out by the cytochrome P- 450 monooxygenase, PicK. Direct comparison of the relative k(cat)/K(m) values for the two substrates, YC-17 and narbomycin, showed a threefold rate preference of pick for narbomycin.
- Graziani, Edmund I.,Cane, David E.,Betlach, Melanie C.,Kealey, James T.,McDaniel, Robert
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p. 3117 - 3120
(2007/10/03)
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