Copper-catalyzed aerobic oxidative C-C bond cleavage of simple ketones for the synthesis of amides
A Cu-catalyzed oxidative amidation of simple ketones with amines via carbon-carbon (C-C) bond cleavage has been developed. A number of aryl and alkyl ketones could be easily converted to amides using cheap copper salt as the catalyst and O2 as the oxidant with a wide range of amines, including primary and secondary amines. This method shows a notable advantage of the broad scope for the substrate, thus providing a practical approach to amides. A plausible mechanism is proposed based on the preliminary experiments.
Li, Ke,Liu, Wei,Liu, Yu-Feng,Yang, Guo-Ping,Zeng, Kai
p. 6958 - 6964
(2020/10/02)
Amide compound with antitumor activity and application of amide compound
The invention belongs to the technical field of pharmaceutical chemistry and particularly provides an amide compound with antitumor activity and application of the amide compound. The structural formula of the amide compound is shown as R1CONHR2, wherein R1 and R2 are independently selected from aryl or heterocycle. The biological activity test result of the compound shows that the compound has a good inhibition effect on histone methyl SET7. Good antitumor aspect development application prospects are achieved.
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Paragraph 0106; 0107; 0108; 0109; 0110
(2017/08/02)
Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773)
High throughput screening of the Roche compound library identified benzanilides such as 1 and 2 as antagonists of TAAR1. Optimisation of this hit series led to the first selective TAAR1 antagonist (N-(3-Ethoxy-phenyl)-4- pyrrolidin-1-yl-3-trifluoromethyl-
Stalder, Henri,Hoener, Marius C.,Norcross, Roger D.
supporting information; experimental part
p. 1227 - 1231
(2011/04/16)
Cyclic hydroxamic acids as oxygenating agents - Conversion of imines to anilides
Cyclic hydroxamic acid mediated functional group modification of an imine to anilide is reported.
Sahadeva Reddy,Pratap Reddy,Reddy
p. 3447 - 3451
(2007/10/03)
Direct Acylamination of Pyridine 1-Oxide with N-Phenylarenimidoyl Chlorides and Fluorides
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Abramovitch, Rudolph A.,Pilski, Jacek,Konitz, Antoni,Tomasik, Piotr
p. 4391 - 4393
(2007/10/02)
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