- Synthesis and structural characterization of (2E,3E)-N1,N 2-Bis(4-chlorobenzylidene)ethane-1,2-diamine
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Present compound (2E,3E)-N1,N2-bis(4- chlorobenzylidene)ethane-1,2-diamine (C16H14C 14N2, Mr = 305.19) was synthesized and characterized by elemental analysis, FT-IR, 1H NMR and single crystal X-ray diffraction. The crystal belongs to monoclinic, space group Cc, with a = 10.166(2), b = 10.345(2), c = 26.650(5) ?, β = 91.91(3)°, V = 2801.1(10) ?3, Z = 8, Dc = 1.447 g/cm3, λ = 0.71073 ?, μ(MoKα) = 0.454 mm-1, F (000) = 1264. The final refinement gave R = 0.0652, wR(F2) = 0.1582 for 4,578 observed reflections with I > 2σ (I). X-Ray diffraction analysis reveals that the asymmetric unit of the title compound consists of two independent molecules. Each independent molecule adopts an E configuration about the central C=N functional bond. The dihedral angles between the two benzene rings are 2.3(2) and 0.5(2)°, respectively in two independent molecules. The molecules are linked through C- H···Cl hydrogen bonds interactions.
- Liang, Zu-Pei,Li, Jian
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Read Online
- Modification of platinum nanoparticles loaded on activated carbon and activated carbon with a new chelating agent for solid phase extraction of some metal ions
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The present study as simple and efficient is based on application of platinum nanoparticle loaded on activated carbon (Pt-NP-AC) which characterized by SEM, TEM and XRD. Pt-NP-AC and activated carbon (AC) that efficiently modified by impregnation of new c
- Ghaedi, Mehrorang,Noormohamadi, Hamid Reza,Asfaram, Arash,Montazerozohori, Morteza,Tashkhourian, Javad,Soylak, Mustafa
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- Phototriggered cytotoxic properties of tricarbonyl manganese(I) complexes bearing α-diimine ligands towards HepG2
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Reaction between bromo tricarbonyl manganese(I) and N,N′-bis(phenyl)-1,4-diaza-1,3-butadiene ligands, bearing different electron-donating and electron-withdrawing groups R?=?OCH3, Cl, and NO2 in the ortho- and para-positions on the p
- Mansour, Ahmed M.,Radacki, Krzysztof,Khaled, Rabaa M.,Soliman, Marwa H.,Abdel-Ghani, Nour T.
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p. 135 - 147
(2021/03/06)
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- Design and application of diimine-based copper(i) complexes in photoredox catalysis
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Structurally different bis(imino)copper(i) complexes were prepared in a highly modular manner and utilized as copper-based photocatalysts in the ATRA reactions of styrenes and alkyl halides. The new photocatalysts showed good catalytic activity and ensured efficient chemical transformations.
- F?ldesi, Tamás,Sipos, Gellért,Adamik, Réka,Nagy, Bálint,Tóth, Balázs L.,Bényei, Attila,Szekeres, Krisztina J.,Láng, Gyz G.,Demeter, Attila,Peelen, Timothy J.,Novák, Zoltán
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supporting information
p. 8343 - 8347
(2019/09/30)
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- Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1
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The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty different genes coding for cy
- Kishk, Safaa M.,McLean, Kirsty J.,Sood, Sakshi,Helal, Mohamed A.,Gomaa, Mohamed S.,Salama, Ismail,Mostafa, Samia M.,de Carvalho, Luiz Pedro S.,Munro, Andrew W.,Simons, Claire
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supporting information
p. 1546 - 1561
(2019/03/05)
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- Facile access to polymer supported zinc–salen complex: highly efficient heterogeneous catalyst for synthesizing hydantoins, thiohydantoins and Schiff bases in aqueous medium
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The synthesis of polymer supported zinc–salen complex (PS-Zn–salen) is described. The mononuclear zinc(II)–salen complex was characterized by Fourier-transform NMR spectroscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectrophotometry (FT-IR), thermogravimetric analysis, scanning electron microscopy, surface area and pore size distribution by Brunauer–Emmett–Teller. The synthesized PS-Zn–salen complex used as a recyclable heterogeneous catalyst for the efficient synthesis of hydantoins, thiohydantoins and Schiff bases in an aqueous medium. The isolated yields of hydantoins, thiohydantoins and Schiff bases achieved up to 89, 95 and 94%, respectively. In spite of conventional heterogeneous catalysts, current PS-Zn–salen complex shows thermal stability up to 280?°C. Moreover, the catalyst could be recovered easily by simple filtration and reused for next run with slightly declining its activity up to six successive runs. The FT-IR spectrum of recycle catalyst after 6th run confirmed that the catalyst was stable during the course of a reaction. The leaching of metal from the PS-Zn–salen is negligible, which was confirmed by AAS and hot filtration test.
- Balinge, Kamlesh Rudreshwar,Khiratkar, Avinash Ganesh,Muskawar, Prashant Narayan,Thenmozhi,Bhagat, Pundlik Rambhau
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p. 2075 - 2097
(2017/12/26)
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- Nano tetraimine Pd(0) complex as an efficient catalyst for phosphine-free Suzuki reaction in water and copper-free Sonogashira reaction under aerobic conditions
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A nano tetraimine Pd(0) complex catalyst was successfully used as an efficient heterogeneous catalyst for the phosphine-free palladium-catalysed Suzuki coupling reaction in water at 80 °C. This nano tetraimine Pd(0) complex was also used for copper-free Sonogashira reaction in dimethylformamide at 100 °C. The catalyst was easily recovered from the reaction mixture by centrifugation and reused for at least six cycles without any significant loss in its catalytic activity. Analysis of the reaction mixture using inductively coupled plasma analysis showed that leaching of palladium from the catalyst was negligible. The reactions can be performed efficiently for aryl iodides, bromides and also chlorides.
- Mandegani, Zeinab,Asadi, Mozaffar,Asadi, Zahra
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p. 657 - 663
(2016/07/19)
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- A nano tetraimine Pd(0) complex: Synthesis, characterization, computational studies and catalytic applications in the Heck-Mizoroki reaction in water
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A new nano tetraimine Pd(0) complex was successfully prepared by the complexation of palladium acetate with an N,N-bisimine ligand. The structural features of the catalyst and the ligand were characterized using different microscopic and spectroscopic techniques such as FT-IR, XRD, XPS, UV-Vis, NMR, and elemental analysis. The morphology of the catalyst was determined using FE-SEM and TEM. The catalyst was effectively employed in the palladium-catalyzed Heck-Mizoroki reaction in water as a green solvent. The catalyst was reusable and recycled six times without any decrease in its catalytic activity. The ICP analysis showed that the catalyst has very little Pd leaching (0.2%) during the reaction process, demonstrating that our catalyst is stable and heterogeneous in practice. Furthermore, we have theoretically explored the feasibility of two neutral and cationic pathways in the density functional theory framework. The geometries and energies of all species involved in the reaction mechanism are analyzed.
- Mandegani, Zeinab,Asadi, Mozaffar,Asadi, Zahra,Mohajeri, Afshan,Iranpoor, Nasser,Omidvar, Akbar
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p. 3326 - 3337
(2015/06/25)
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- Synthesis, ir and nmr spectral correlations in some symmetrical diimines
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A series of diimines have been synthesized by coupling of diamine with substituted benzaldehydes. The purities of these diimines were checked by their analytical and spectroscopic data. The spectral frequencies vCN (cm-1), NMR chemical shifts (v, ppm) of C-H and C=N of these diimines have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied.
- Thirunarayanan
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- A new family of doubly cyclopalladated diimines. A remarkable effect of the linker between the metalated units on their cytotoxicity
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The cyclopalladation of a series of symmetric diimines with the formula (RC6H4CH=NZ)2, where Z = CH2 or (CH2)2OCH2 and R = p-Cl, p-OMe, p-NO 2, and o-Cl, is described. Optimal conditions to obtain the dimetalated compounds were found to be palladium(II) acetate, in toluene, at 60 °C and with a reaction time of 2-4 h. The reactivity of the dimetalated compounds with monodentate, bidentate, and bis(monodentate) Lewis bases was also studied. The cytotoxic activity of some selected compounds was evaluated against a panel of adenocarcinoma cell lines (colon HCT116 and breast MCF7 and MDA-MB231). Compounds containing the fragment NCH2CH 2OCH2CH2OCH2CH2N exhibited a remarkable cytotoxic activity in the three cancer cells assayed, but complexes containing the NCH2CH2N fragment showed no activity. It seems that the length and flexibility of the central saturated chain in the imine molecule, as well as its lipophilicity and hydrophilicity, explain the different cytotoxicity of the two series of coordination compounds here reported.
- Albert, Joan,Bosque, Ramon,Cadena, Magali,D'Andrea, Lucia,Granell, Jaume,Gonzalez, Asensio,Quirante, Josefina,Calvis, Carmen,Messeguer, Ramon,Badia, Josefa,Baldoma, Laura,Calvet, Teresa,Font-Bardia, Merce
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supporting information
p. 2862 - 2873
(2014/06/24)
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- Synthesis of new antifungal 1,2,4-bis-oxadiazolines using cycloaddition reaction of nitrile oxide with bis-Schiff base
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A series of arylaldehydes and acetophenone when treated with 1,2-ethanediamine afford the bis-Schiff bases N,N'- bis(arylidene)-ethane-l,2- diamines 1-8, N,N'-bis(arylmethylene)-ethane-l,2-diamines 9-10 and the N,N'-bis(l- phenylethylidene)-ethane-l,2-dia
- Toumi, Ahmed,Daami-Remadi, Mejda,Jannet, Hichem Ben
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p. 922 - 928
(2013/08/15)
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- Direct synthesis of imines via solid state reactions of carbamates with aldehydes
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Various solid carbamates were prepared from the reactions of liquid amines with carbon dioxide in an autoclave and these carbamates were used as stable, efficient alternatives for toxic liquid amines. Solid-state grinding of carbamates and aldehydes, using a mortar and pestle, produced imines as the sole products in greater than 97% yields. Complete conversions were generally accomplished within a day at 25 °C without using solvents or additives. Reaction rates were drastically enhanced upon increasing the reaction temperature. In contrast, reactions of aldehydes with liquid amines in the presence of solvent or in neat conditions afforded imines in moderate yields along with by-products.
- Lee, Byeongno,Lee, Kyu Hyung,Lim, Byung Wook,Cho, Jaeheung,Nam, Wonwoo,Hur, Nam Hwi
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p. 389 - 394
(2013/05/08)
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- Dinuclear five-coordinate copper(II) complexes with chelating diphosphonic acid ligands: Hydrothermal synthesis, structure, and thermal properties
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The synthesis of two new diphosphonic acid ligands,[ethane-1, 2-diylbis(azanediyl)]bis[(4-chlorophenyl)methylene]diphosphonic acid (L 1P), [ethane-1, 2-diylbis(azanediyl)]bis[(4-bromophenyl)methylene] diphosphonic acid (L2P), and the
- Dehghanpour, Saeed,Asadizadeh, Saeedeh,Assoud, Jalil
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experimental part
p. 861 - 867
(2012/08/07)
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- Synthesis, antimicrobial activity and structure-activity relationship study of N,N-dibenzyl-cyclohexane-1,2-diamine derivatives
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We report herein synthesis and antimicrobial activity of a series of N,N-dibenzyl-cyclohexane-1,2-diamine derivatives. In order to study the structure-activity relationship of substituted dibenzyl-cyclohexane-1,2-diamine derivatives, 44 structurally diverse compounds were synthesized and tested against Gram-positive and Gram-negative bacterial strains. Among them, compounds 17-20, 26, 37, 38 were found to be more active than tetracycline with MIC value ranging 0.0005-0.032 μg/mL and no hemolysis upto 1024 μg/mL in mammalian erythrocytes was observed. Some of the compounds have also shown very promising antifungal activity against Candida albicans, Candida glabrata and Geotrichum candidium.
- Sharma, Mukul,Joshi, Penny,Kumar, Nitin,Joshi, Seema,Rohilla, Rajesh K.,Roy, Nilanjan,Rawat, Diwan S.
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experimental part
p. 480 - 487
(2011/03/19)
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- Synthesis and characterization of some four coordinated zinc(ii) and mercury(II) complexes
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Several new symmetrical bidentate Schiff base ligands (L1= N,N-bis(4-chlorobenzylidene)ethane-1,2-diamine, L2= N,N-bis(3- nitrobenzylidene)ethane-1,2-diamine and L3= N,N-bis(4- nitrobenzylidene)ethane-1,2-diamine and their zinc(II) and mercury(II) complexes with general formula MLX2 in which X= Cl-, Br -and I- and M=Hg(II) and Zn(II) have been prepared and characterized by elemental analysis, 1H NMR, 13C NMR, Fourier transform-infrared and ultraviolet-visible spectra and molar conductance. All compounds are nonelectrolytes in dimethylformamide. The molar conductance and spectral properties indicate coordination of halides ions to metal in pseudo-tetrahedral geometry.
- Montazerozohori,Nouroozi,Hashemi,Kazemi,Joohari,Musavi
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experimental part
p. 5399 - 5402
(2012/07/01)
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- New Re(I) tricarbonyl-diimine complexes with N,N′-bis(substituted benzaldehyde)-1,2-diiminoethane Schiff base ligands: Synthesis, spectroscopic and electrochemical studies and crystal structures
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The syntheses, structures and spectroscopic properties of tricarbonylrhenium(I) complexes with N,N′-bis(2-bromo, 4-bromo, 4-chloro and 3-methoxybenzaldehyde)-1,2-diiminoethane Schiff base ligands have been investigated in this paper. Characterization of t
- Mirkhani, Valiollah,Kia, Reza,Vartooni, Akbar Rostami,Fun, Hoong-Kun
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experimental part
p. 1600 - 1606
(2010/06/20)
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- Aromatic oxidative decompositions of copper Schiff base complexes
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Copper Schiff base complexes used in enantioselective aziridination reactions were shown to possess a proclivity for aromatic oxidative coupling reactions.
- Andrez, Jean-Christophe
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supporting information; experimental part
p. 4225 - 4228
(2009/10/26)
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- A convenient "one-pot" reaction for selective monoalkylation of N,N′-disubstituted ethylenediamines
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A study on the scope of the method to obtain N,N,N′-trisubstituted ethylenediamines III by monoalkylation of N,N′-disubstituted ethylenediamines I through a "one-pot" reaction is presented. It involves condensation of compounds I with aldehydes followed by reduction of the formed imidazolidines II without previous isolation.
- Salerno, Alejandra,Figueroa, Maria Amalia,Perillo, Isabel A.
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p. 3193 - 3204
(2007/10/03)
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- Tetrahydroimidazoles - A promising group of expected NSAIDS - Their synthesis and anti-inflammatory activity
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Several new 1, 2, 3-trisubstituted tetrahydroimidazoles (11-28) have been synthesised and their structures elucidated on the basis of spectral data. These compounds show promising anti-inflammatory activity by carrageenin induced paw edema test in rats and few of them showed an activity better than indomethacin.
- Khan,Chawla, Gita
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p. 653 - 663
(2007/10/03)
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- Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties
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Ethylenediamine was reacted with suitable aromatic aldehydes in order to prepare their respective diSchiff bases. These compounds were then reduced to give the corresponding tetrahydrodiSchiff bases, which were low melting in nature. Finally, these derivatives were condensed with different aromatic aldehydes to give the desired tetrahydroimidazoles. The structures of all these compounds were established on the basis of spectral data. These novel tetrahydroimidazoles showed promising anti-inflammatory and analgesic activity. The compounds were also screened for their anti-bacterial property against Staphylococcus aureus and Escherichia coli.
- Sharma, Vibha,Khan
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p. 651 - 658
(2007/10/03)
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- Studies on Thiazolidinones. Part-XIV: Synthesis of 3,3'-Bisthiazolidinones and 2,2-Disubstituted Thiazolidinones from Azomethines
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Several new 3,3'-bisthiazolidinones (III) and 2,2-disubstituted thiazolidinones (VIII) have been synthesised by the cycloadditive dehydration of thioglycolic acid to the azomethin derivatives (II) and (VII) prepared from the aliphatic diamines and heterocyclic monoamines respectively.The structure of the compounds have been confirmed from the spectral data and elemental analysis.The fungicidal and bactericidal activities of the compounds have also been evaluated.
- Sahu, J.,Sahu, T. K.,Naik, S. K.,Nayak, A.
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p. 861 - 863
(2007/10/02)
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