- Electron Spin Resonance Spin-Trapping Analysis of γ-Induced Radicals in Polycrystalline α-D-Glucose
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γ-Induced radicals in polycrystalline α-D-glucose are trapped with a water-ethanol solution of 2-nitroso-2-methylpropane.Five long-lived nitroxide spin-adducts are evidenced by electron spin resonance (ESR).Specifically labeled glucoses are also studied.Tentative assignments are discussed for each nitroxide radical.
- Thiery, C. J.,Agnel, JP. L.,Frejaville, C. M.,Raffi, J. J.
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Read Online
- A stable isotope labeled β receptor agonist synthetic method of compound
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The invention relates to a synthesis method of a stable isotope-labeled beta receptor agonist type compound. The synthesis method comprises the following steps: (1) by taking stable isotope-labeled methanol as a raw material, reacting with acetone or stable isotope-labeled acetone, and ammonifying to obtain stable isotope-labeled tert-butylamine; and (2) by taking a bromoketone type compound as a precursor of the beta receptor agonist type compound, reacting with stable isotope-labeled tert-butylamine to prepare the stable isotope-labeled beta receptor agonist type compound. Compared with the prior art, the method for preparing the stable isotope-labeled beta receptor agonist, provided by the invention, is simple, safe and reliable, the chemical purity of the product after separation and purification is above 99.0%, the isotopic abundance is above 98.0% atom, and the product can fully meet the requirements of residual detection in the field of food safety.
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Paragraph 0064; 0065; 0066
(2017/04/29)
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- Synthesis of stable isotope labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol
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Three stable and simple synthetic routes of labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to 1H NMR and liquid chromatography-tandem mass spectrometry.
- Tu, Yahui,Zhong, Jiaqi,Wang, Haoran,Pan, Jie,Xu, Zhongjie,Yang, Weicheng,Luo, Yong
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p. 546 - 551
(2016/11/23)
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