The synthesis of racemic cytisine 1 has been completed using (i) N-selective alkylation of 6-bromopyridone with bromide 6 and (ii) Pd(o) mediated intramolecular a-arylation of lactam 8 as key steps to achieve rapid assembly of the tricyclic core skeleton of the lupin alkaloids.
Botuha, Candice,Galley, Carl M. S.,Gallagher, Timothy
p. 1825 - 1826
(2007/10/03)
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