- "Methylene Bridge" to 5-HT3 Receptor Antagonists: Conformationally Constrained Phenylguanidines
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Arylguanidines, depending upon their aromatic substitution pattern, display varying actions at 5-HT3 receptors (e.g., partial agonist, agonist, superagonist). Here, we demonstrate that conformational constraint of these agents as dihydroquinazo
- Abdelkhalek, Ahmed S.,Alley, Genevieve S.,Alwassil, Osama I.,Khatri, Shailesh,Mosier, Philip D.,Nyce, Heather L.,White, Michael M.,Schulte, Marvin K.,Dukat, Ma?gorzata
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p. 1380 - 1389
(2018/11/23)
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- Novel guanidinobenzamides
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Compounds of formula IA and IB are new where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceutical form
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