- Synthesis and antitussive activity of obtucarbamate A derivatives
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Obtucarbamate A was purified from Disporum cantoniense with good antitussive property. In present work, a series of obtucarbamate A derivatives were designed and synthesized from obtucarbamate A by microwave method, and their antitussive activity were evaluated. The results showed that the toluene diisocyanate was obtained with a yield of 95.1percent using a simple method, 1-methyl-2-pyrrolidinone as solvent, temperature of 190 °C, microwave irradiation at 60 W power for 30 min. All compounds have good antitussive activity, and small steric hindrance unsaturated groups of ester chains and amino groups favor activity. It is the first reported of obtucarbamate A derivatives used as antitussive, and the results provide a basis for the application of obtucarbamate derivatives as new antitussive.
- Gan, Xiuhai,Liang, Zhiyuan,Ma, Xiaoyun,Wei, Gang,Zhou, Qingdi
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supporting information
(2020/06/01)
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- METHOD FOR PRODUCING URETHANES COMPOSED OF DI-FUNCTIONAL AROMATIC AMINES AND DIALKYL CARBONATES
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A process for preparing urethanes by reacting aromatic diamines with a dialkyl carbonate, wherein the alkyl radical of the organic dialkyl carbonate comprises 2-18 carbon atoms and one or more heteroatoms and the reaction is performed in the presence of a
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Page/Page column 3
(2011/06/24)
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