- BIVALENT LECA INHIBITORS TARGETING BIOFILM FORMATION OF PSEUDOMONAS AERUGINOSA
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The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.
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Page/Page column 45; 48-49
(2021/05/15)
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- Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques
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The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for β-amyloid (Aβ) binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthesized and evaluated. Most of them displayed good affinity (Ki1-42aggregates, and some ligands even showed values of Kiless than 10 nM. Structure-activity relationship analysis revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development of Aβ imaging agents.
- Jia, Jianhua,Zhang, Longfei,Song, Jia,Dai, Jiapei,Cui, Mengchao
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p. 4089 - 4100
(2020/12/13)
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- DISAZO YELLOW PIGMENT, PIGMENTS DISPERSION AND PHOTOSENSITIVE RESIN COMPOSITION USING THE SAME
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Novel pigment yellow formation of pigment dispersion including oh settlement compound and disclosure photosensitive resin composition are disclosed. Said discharge oh settlement compounds are high heat resistance and excellent dispersion property, the dispersion of pigment dispersion including same on the base and storage stability. The, said discharge oh settlement using the photosensitive resin compositions have a good coloring compounds including pigment dispersion can be implementing force, such as a high-quality color filter having an excellent optical brightness and contrast can be [...] number. (by machine translation)
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Paragraph 0145; 0146; 0148; 0158-0161
(2019/06/11)
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- Liquid crystal dimers having vary oxyethylene flexible spacers
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In this article, we are prepared that the liquid crystal dimers have aromatic-ester type mesogenic units or aromatic-Schiff base type mesogonic units and confirmed by 1H-NMR spectrometry. The mesomorphic and optical properties of the resultant dimers were studied by differential scanning calorimetry and polarizing optical microscopy.
- Park, Joo Hoon,Singu, Bal Sydulu,Choi, Ok Byung,Lee, Hwan Myung,Lee, Jin Young,Kim, Sung Jo,Cha, Eun Hee,Park, Seon Nam,Kwak, Myeong Heon,So, Bong Keun,Kim, Ran Hee,Lee, Soo Min,Yoon, Kuk Ro
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- New optically active Organo-soluble poly(amide-Imide)s from [N,N?-(4,4?- Diphtaloyl)-BIS-l-amino Diacid]s and 1,2-bis[4,4'-aminophenoxy] ethane: Synthesis and characterization
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Six new dicarboxylic acids 3a-f were synthesized by the reaction of 3,3?,4,4?-biphenyltetracarboxylic dianhydride (BPDA) 1 with L-amino acids 2a-f in a solution of glacial acetic acid/pyridine (Py) at refluxing temperature. Then six new optically active p
- Feyzi, Akram,Faghihi, Khalil,Raeisi, Ahamd,Koushki, Maryam,Farahani, Mansoure
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p. 1884 - 1887
(2014/03/21)
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- Preparation of new optically active and thermally stable poly(amide-imide) containing bicyclo segment and ether group in the main chain by direct polycondensation in two different media
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A new series of optically active and thermally stable poly(amide-imide)s (PAIs) with good inherent viscosities based on bicyclo diacids and etheric diamine in the main chain were synthesized from the direct polycondensation reaction of N,N?-(bicyclo[2,2,2
- Faghihi, Khalil,Shabanian, Meisam
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scheme or table
p. 491 - 496
(2011/12/02)
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- Synthesis of symmetric liquid crystal dimers based on 1,2-bis{-[-(4- alkoxybenzoyloxy)benzylidene]amino)phenoxy}ethane and investigation of phase behaviour by varying alkoxy terminal chain length
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With the objective to study the effect of alkoxy terminal chain length on mesomorphic properties of liquid crystals, We have synthesized ester and Schiff base dimers from diamine derivative containing 1,2-dioxyethylene as short spacer with aldehyde deriva
- Lee, Chang Sin,Kim, Tae Hyeong,Ramaraj,Ryu, Seok Gn,Song, Hyun Hoon,Lee, Soo-Min,Yoon, Kuk Ro
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experimental part
p. 117 - 129
(2010/03/03)
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- Synthesis and Properties of a New Series of Troegerophanes
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A new series of macrocyclic compounds with one or two Troeger base skeletons has been synthesized by condensing mono-, di-, tri-, and teraethyleneglycol bis(p-aminophenoxy) ethers with formalin in the presence of concentrated hydrochloric acid in ethanol at room temperature for 13 days. This simple one-step cyclization provided 19 in remarkably high yield (46%) and 17, 18, and 20 in yields reflecting the strain of the rings and statistical factors. Complexation with lithium thiocyanate was observed for 20, the structure of which was elucidated by X-ray crystallography.
- Ibrahim, Alhussein A.,Matsumoto, Mutsumi,Miyahara, Yuji,Izumi, Kenji,Suenaga, Masahiko,Shimizu, Nobujiro,Inazu, Takahiko
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p. 209 - 215
(2007/10/03)
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- Bis-(4-isocyanatophenoxy)-alkanes and a process for the production thereof
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Bis-(4-isocyanatophenoxy)-alkanes corresponding to the formula STR1 in which R represents a divalent, saturated aliphatic hydrocarbon radical having from 2 to 6 carbon atoms with at least two carbon atoms between the two ether oxygen atoms, and R' represents hydrogen or a methyl group with R' being the same on both rings, are produced by phosgenating the corresponding diamine or an adduct of the corresponding diamine. These diisocyanates are particularly useful in the production of isocyanate addition products having outstanding physical and mechanical properties.
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- Novel Bis as Antitrypanosomal Agents
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A series of novel 1,1'-(4,1-phenylene)bis was prepared and evaluated for activity against Trypanosoma rhodesiense in mice.The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed.The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends encouragement to further development of this structural class.
- Turner, William R.,Werbel, Leslie M.
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p. 1728 - 1740
(2007/10/02)
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- MESOGENIC POLYMERS. 6. TWO SERIES OF ISOMERIC POLYAZOMETHINES.
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Two homologoous series of alternating rigid-flexible, main chain liquid crystalline polyimines are reported; one based on terephthaldehyde the other based on p-phenylenediamine. It was found through examination of optical microscopic, x-ray diffraction an
- Griffin,Britt,Hung,Steele
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p. 305 - 314
(2007/10/02)
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- Poly(6-oxy-2,2,4-trialkyl-1,2-dihydroquinoline)alkylene compounds as antidegradants for rubber
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Vulcanizable or vulcanized diene elastomers containing stabilizing amounts of certain poly(6-oxy-2,2,4-trialkyl-1,2-dihydroquinoline)alkylene antidegradants show resistance to ozone attack. The antidegradants themselves are novel compounds.
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