- Designer ligands for beryllium
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We report the rational design of ligands that selectively bind beryllium. We selected two ligands to design Be based on binding polynulear species with a Be-O-Be motif: 2-hydroxyisophthalic acid (HIPA) and 2,3-dihydroxybenzoic acid (DHBA). All previous wo
- Keizer, Timothy S.,Sauer, Nancy N.,McCleskey, T. Mark
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Read Online
- Complexes and Ligands
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The present application provides ligands and fluorescent or luminescent complexes comprising these ligands.
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Paragraph 0055
(2022/02/05)
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- Slow Formation of Pseudorotaxanes in Water
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The synthesis of two water-soluble oligophenylene-ethynylene (OPE)-rods with substituted iso- and terephthalate end groups is presented. Both undergo slow association with a Diederich-type cyclophane in aqueous solution. Formation of [2]pseudorotaxanes oc
- Aeschi, Yves,Jucker, Laurent,H?ussinger, Daniel,Mayor, Marcel
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supporting information
p. 3384 - 3390
(2019/02/19)
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- High-relaxivity Gd(III)-hemicryptophane complex
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The polytopic hemicryptophane cage HC1 combining a cyclotriveratrylene (CTV) unit and a tris(2-aminoethyl)amine (tren) moiety connected by three 2-hydroxyisophthalamide linkers was synthesized in 12 steps. The resulting highly functionalized covalent host
- Godart, Estelle,Long, Augustin,Rosas, Roselyne,Lemercier, Gilles,Jean, Marion,Leclerc, Sébastien,Bouguet-Bonnet, Sabine,Godfrin, Célia,Chapellet, Laure-Lise,Dutasta, Jean-Pierre,Martinez, Alexandre
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supporting information
p. 1999 - 2003
(2019/04/11)
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- Tenacic Acids: A New Class of Tenacious Binders to Metal Oxide Surfaces
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The backbone of 2-hydroxyisophthalic acid was identified as a potential metal oxide anchor because of the perfect alignment of all three of its donor groups for binding to inorganic surfaces. It can therefore be used in the design of organic linkers for m
- Komati, Rajesh,Mitchell, Carl A.,LeBeaud, Anastasia,Do, Huy,Goloverda, Galina Z.,Kolesnichenko, Vladimir L.
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supporting information
p. 14824 - 14829
(2018/09/12)
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- Functionalized hydrazide macrocycle ion channels showing pH-sensitive ion selectivities
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Transmembrane channels formed by functionalized hydrazide macrocycles are reported. The different pH values of buffer solutions have a significant effect on the K+/Cl- selectivity of the macrocycles. This unique transport behavior is
- Xin, Pengyang,Tan, Si,Wang, Yaodong,Sun, Yonghui,Wang, Yan,Xu, Yuqing,Chen, Chang-Po
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supporting information
p. 625 - 628
(2017/01/13)
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- One-pot formation of hydrazide macrocycles with modified cavities: An example of pH-sensitive unimolecular cation channels
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A series of pH-sensitive, cation-selective hydrazide macrocyclic channels have been synthesized. The macrocyclic channels bear multiple carboxyls in the inner cavity, which have a significant impact on their membrane-incorporation ability and NH4/su
- Xin, Pengyang,Tan, Si,Sun, Yonghui,Ren, Qiaojv,Dong, Wenpei,Guo, Jingjing,Jiang, Tao,Chen, Chang-Po
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supporting information
p. 5322 - 5325
(2017/07/07)
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- 2-HYDROXYISOPHTHALIC ACID AND ITS DERIVATIVES: METHODS OF MAKING AND APPLICATIONS
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Substituted derivatives of 2-hydroxyisophthalic acid are provided, as well as new synthetic routes for making 2-hydroxyisophthalic acid and the substituted derivatives. Potential uses of the derivatives in a variety of applications are also provided.
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Paragraph 0027; 0043-0045
(2018/04/12)
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- Ultrabright Lanthanide Nanoparticles
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Tb-doped La0.9Tb0.1F3 nanoparticles were prepared by a simple and reproducible microwave-assisted synthetic protocol in water. The nanoparticles were characterized by XRD, TEM, dynamic light scattering and inductively coup
- Goetz, Joan,Nonat, Aline,Diallo, Abdoulaye,Sy, Mohamadou,Sera, Ildan,Lecointre, Alexandre,Lefevre, Christophe,Chan, Chi Fai,Wong, Ka-Leung,Charbonnière, Lo?c J.
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p. 526 - 534
(2016/07/06)
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- Siderophore inspired tetra- and octadentate antenna ligands for luminescent Eu(III) and Tb(III) complexes
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Following the success of the siderophore-inspired 1,2-hydroxypyridonate (HOPO) and 2-hydroxisophthalamide (IAM) chromophores in Eu(III) and Tb(III) luminescence, we designed three new ligands bearing both chromophores. Syntheses of the octadentate ligands
- Daumann, Lena J.,Werther, Philipp,Ziegler, Michael J.,Raymond, Kenneth N.
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p. 263 - 273
(2016/11/11)
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- Inclusion complex containing epoxy resin composition for semiconductor encapsulation
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The invention is an epoxy resin composition for sealing a semiconductor, including (A) an epoxy resin and (B) a clathrate complex. The clathrate complex is one of (b1) an aromatic carboxylic acid compound, and (b2) at least one imidazole compound represented by formula (II): wherein R2 represents a hydrogen atom, C1-C10 alkyl group, phenyl group, benzyl group or cyanoethyl group, and R3 to R5 represent a hydrogen atom, nitro group, halogen atom, C1-C20 alkyl group, phenyl group, benzyl group, hydroxymethyl group or C1-C20 acyl group. The composition has improved storage stability, retains flowability when sealing, and achieves an effective curing rate applicable for sealing delicate semiconductors.
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- A series of 3D metal organic frameworks based on [24-MC-6] metallacrown clusters: Structure, magnetic and luminescence properties
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Four isostructural metal organic frameworks (MOFs), namely [Co 6(HipO)6]·6H2O (1), [Mn 6(HipO)6]·6H2O (2), [Cd 6(HipO)6]·6H2O (3) and [Zn 6(HipO)6]·7H2O (4) (H3ipO = 2-hydroxyisophthalic acid), were synthesized and structurally characterized. They have a 3D (4,6)-connected framework based on [24-MC-6] metallacrown clusters ([24-MC-6]-based MOFs). The arrangements of the 24-MC-6 metallacrown SBUs show a regular change indicated by the orientation of their symmetry axes, resulting in a special dense packing mode different from other [24-MC-6]-based MOFs. The analysis of SQUID measurements reveal that compound 1 displays the dominant antiferromagnetic exchanges in 300-10 K between the adjacent Co(ii) ions and a ferromagnetic-like behavior at lower temperatures, whereas compound 2 shows an antiferromagnetic interaction between the adjacent Mn(ii) ions. Compound 1 exhibits a magnetocaloric effect (MCE) with the resulting entropy change (-ΔSm) of 15.20 J kg-1 K-1 for ΔH = 50 kG at 6 K, which is the highest value among the cobalt-based MOFs with MCE reported so far. The luminescence properties of compounds 3 and 4 were studied, both of them exhibit photoluminescence in the solid state at room temperature which can be ascribed to intraligand π→π* transitions. This journal is the Partner Organisations 2014.
- Wang, Kai,Zou, Hua-Hong,Chen, Zi-Lu,Zhang, Zhong,Sun, Wei-Yin,Liang, Fu-Pei
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supporting information
p. 12989 - 12995
(2014/08/18)
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- DI-MACROCYCLES
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The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
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Paragraph 00184
(2014/06/11)
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- Labile linkage for compound delivery to a cell
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Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different mo
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Page/Page column 7
(2010/02/11)
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- BENZAMIDINE DERIVATIVES
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Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.
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- Effects of alkali and alkaline earth metals on the Kolbe-Schmitt reaction
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It was found that the carboxylations of magnesium, calcium, and barium phenoxides with carbon dioxide at 260 °C produced salicylic acid and dicarboxylic acids (4-hydroxyisophthalic acid and 2-hydroxyisophthalic acid) in very high yields (80-100%), exceeding that of the ordinary Kolbe-Schmitt reaction. The orientation (ortho/para ratio) was controlled not only by chelations of the intermediate with alkaline earth metal (Mg, Ca, Ba) ions, resulting in salicylic acid, but also by the sizes of metal ions (Rb, Cs), giving p-hydroxybenzoic acid in a much higher ratio than the widely used method with potassium or sodium phenoxide. These alkaline earth metals worked to produce 3-hydroxy-2-naphthoic acid by the reaction of 2-naphthoxide with carbon dioxide, but the yield of 6-hydroxy-2-naphthoic acid was comparable to that of 3-hydroxy-2-naphthoic acid when cesium or rubidium 2 naphthoxide was employed. Considerably high yields (～60%) of 6-hydroxy-2-naphthoic acid, a monomer of one of the best liquid-crystal polymers, was attained by the carboxylation of cesium or rubidium 2-naphthoxide in the presence of potassium or sodium carbonate, where the alkali metal ion was supposed to increase the reactivity of the substrate. The formation of "binol" was observed in the preparation of 2-naphthoxides with metal hydroxides, especially with copper(II) ion.
- Rahim, Mohammad Abdur,Matsui, Yoshihisa,Kosugi, Yoshio
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p. 619 - 622
(2007/10/03)
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- Aromatic Nitro-group Displacement Reactions. Part 3. Minor Products of the o-Cyanophenol Synthesis
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In dipolar aprotic solvents, the action of cyanide ions on a moderately activated aromatic or heteroaromatic nitro-compound yields, in addition to the o-cyanophenol, a range of products generated through nitro-group reduction.
- Gorvin, John H.
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p. 738 - 762
(2007/10/02)
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- Metal Ion Catalysis by Blocking Inhibitory Reverse Paths in the Hydrolysis of 3-Carboxyaspirin
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The hydrolysis of 3-carboxyaspirin (1) was kinetically investigated in the presence or absence of tri- or divalent metal ions.The spontaneous hydrolysis of the neutral and the monoanionic forms of 1 involves anhydride intermediates formed by the nucleophi
- Suh, Junghun,Chun, Keun Ho
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p. 3057 - 3063
(2007/10/02)
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- Preparation of cyanophenols
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A process for the preparation of a cyanophenol of formula (I) SPC1 wherein Z is a substituent in the 4- or 6-position with respect to the hydroxy group, characterized in that cyanide ions are reacted in a dipolar aprotic solvent with a nitrobenzene of formula (II) SPC2 wherein Z has the same value as in formula (I) and is a group, other than a nitro group, known to withdraw electrons in substitution reactions and which does not contain a proton capable of ionizing under the defined reaction conditions if such ionization would inhibit the electron-withdrawing effect of the group Z. In formula (I) and (II) the benzene ring is optionally substituted by one or more non electron-withdrawing groups, or by one or more electron-withdrawing groups provided that such electron-withdrawing groups are in positions other than the 4- and 6-positions with respect to the hydroxy group. The compounds of formula (I) are of value in being readily hydrolysed to the corresponding salicylic acids of formula (III) SPC3 certain of which have been described in the literature as possessing a variety of pharmacological properties.
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