- TRICYCLIC ANALOGUES OF THE ANTIALLERGIC AGENT OXATOMIDE: 1-(3-(4-(10,11-DIHYDRO-5H-DIBENZOCYCLOHEPTENE-5-YL)-1-PIPERAZINYL)PROPYL)-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE AND THE RELATED 6,11-DIHYDRODIBENZOTHIEPIN, 4,9-DIHYDROTHIENO-2-BENZOTHIEPIN, AND ...
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11-Chloro-6,11-dihydrodibenzothiepin and its 2-methyl derivative VI were transformed via the 11-(4-(ethoxycarbonyl)-1-piperazinyl) compounds IVc and Vc to 11-(1-piperazinyl) compounds IVb and Vb.Their reactions with 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one (II) afforded the title compounds IVa and IVb.Similar reactions and sequences in the series of 10,11-dihydro-5H-dibenzocycloheptene, 4,9-dihydrothieno-2-benzothiepin, and 10,11-dihydrodibenzothiepin led to further oxatomide (Ia) analogues IIIa and VIIa-XIa.In the test of passivecutaneous anaphylaxis in rats, compound VIIIa was more active than Ia, and IVa had similar activity like Ia.
- Jilek, Jiri,Holubek, Jiri,Svatek, Emil,Metys, Jan,Frycova, Hana,et al.
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p. 870 - 883
(2007/10/02)
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- A New Approach to 1-Alkyl-1,3-dihydro-2H-benzimidazol-2-ones
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A new procedure for preparing 1-alkyl-1,3-dihydro-2H-benzimidazol-2-ones from o-nitroanilines by succesive ethoxycarbonylation, catalytic hydrogenation and thermal cyclization under neutral conditions is described. - (Keywords: Thermal cyclization)
- Gomez-Parra, Vicente,Sanchez, Felix,Torres, Tomas
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p. 639 - 644
(2007/10/02)
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