cas 606143-52-6, Selumetinib | Articles data ｜lookchem

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606143-52-6

Articles about 606143-52-6Total 6 be found

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Synthesis method of semetinib
The invention relates to a synthesis method of simetinib. According to the method, diethoxymethane is creatively adopted as a ring closing reactant, and two-step reaction of ring closing reaction and methylation is combined into one step, so the yield is
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(2021/05/08)

Method for preparing semetinib
The invention relates to a method for preparing an MEK1/2 inhibitor smeltinib, which comprises the following steps: carrying out three-step reaction on the synthetic route to synthesize the smeltinib, carrying out post-treatment on the synthetic method wi
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Paragraph 0057-0063

(2021/04/21)

INTERMEDIATES OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MAP2K OR MEK) INHIBITORS AND PROCESS FOR THEIR PREPARATION
The present invention relates to intermediates of Mitogen-activated protein kinase kinase (MAP2K or MEK) inhibitors such as Selumetinib, Binimetinib and process for their preparation. The present invention also relates to process for the 5 preparation of MEK inhibitors such as Selumetinib, and Binimetinib.
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Page/Page column 12

(2018/04/21)

NOVEL HYDROGEN SULFATE SALT
The present invention relates to Compound 1 hydrogen sulfate salt and solvates, crystalline forms and amorphous forms thereof, and to processes for their preparation. Compound I
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Page/Page column 21-22

(2008/06/13)

N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS
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Page 23

(2008/06/13)

N3 alkylated benzimidazole derivatives as MEK inhibitors
Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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Page 23

(2008/06/13)

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Chemical Properties

Appearance/Colour :White or pale white solid.
Density: 1.692 g/cm³
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)
Storage Temp.:-20°
PKA: 14.20±0.10(Predicted)
PSA: 88.41000
LogP: 3.98950

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