- 3-FLUOROBENZODIAZEPINES
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Benzodiazepines that bear a fluorine substituent in the metabolically active C-3 position were prepared by the reaction of diethylaminosulfur trifluoride (DAST) with the corresponding 3-hydroxybenzodiazepines.These products are surprisingly stable to hydrolysis and possess potent antianxiety and muscle-relaxing properties.
- Middleton, W. J.,Bingham, E. M.,Smith, D. H.
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p. 557 - 572
(2007/10/02)
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- 3-Fluorobenzodiazepines and compositions and uses thereof
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3-Fluorobenzodiazepines, such as 3-fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one, useful as tranquilizers, muscle relaxants, and sedatives.
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- 3-Fluorobenzodiazepines
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3-Fluoro-2,3-dihydro-1H-1,4-benzodiazepin-2-ones of the formula STR1 wherein R1 is H, alkyl or fluorinated alkyl of 1-4 carbon atoms and up to 9 fluorine atoms or cycloalkylalkyl of 4-8 carbon atoms; R2 is phenyl; monohalophenyl or pyridyl; R3 is F, Cl, Br or NO2, and physiologically acceptable acid addition salts thereof, are central nervous system depressants.
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