Iron-Catalyzed Triazole-Enabled C-H Activation with Bicyclopropylidenes
C-H/C-C functionalizations with oxymethylated bicyclopropylidenes were accomplished with an iron catalyst under external oxidant-free conditions. The combination of the unique reactivity of bicyclopropylidenes with a robust iron(II) catalyst enabled C-C c
Mo, Jiayu,Messinis, Antonis M.,Oliveira, Joa? C. A.,Demeshko, Serhiy,Meyer, Franc,Ackermann, Lutz
p. 1053 - 1064
(2021/01/26)
PROCESS OF MAKING CFTR MODULATORS
The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
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Paragraph 0418; 0422; 0423; 0756; 757
(2021/02/19)
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
Compounds of Formula (I) pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
Meijere, Armin de,Kozhushkov, Sergei I.,Sp?th, Thomas,Geneste, Florence,Holmes, Andrew B.
p. 142 - 142
(2017/09/13)
A New General Approach to Bicyclopropylidenes
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Meijere, Armin de,Kozhushkov, Sergei I.,Spaeth, Thomas,Zefirov, Nikolai S.
p. 502 - 505
(2007/10/02)
OLIGOMETHYLENATION OF BICYCLOPROPYLIDENE BY DIAZOMETHANE IN THE PRESENCE OF PALLADIUM(II) ACETATE
Oligomethylenation, leading to the inclusion of three or four equivalents of methylene in the molecule, takes place during the reaction of bicyclopropylidene with diazomethane in the presence of palladium(II) acetate.
Lukin, K. A.,Kuznetsova, T. S.,Kozhushkov, S. I.,Piven', V. A.,Zefirov, N. S.
p. 1483 - 1486
(2007/10/02)
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