- PROGRANULIN MODULATORS AND METHODS OF USING THE SAME
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Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemporal dementia (FTD).
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Paragraph 0310-0311
(2020/12/30)
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- COMPOUNDS AND METHODS OF USE THEREOF
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Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.
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Page/Page column 143
(2011/02/24)
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- Synthesis and herbicidal activity of diphenyl ether derivatives containing unsaturated carboxylates
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A series of novel diphenyl ether derivatives containing unsaturated carboxylates were designed and synthesized. Their structures were identified by 1H nuclear magnetic resonance and elemental analyses. The bioassays indicated that the compounds 5b and 5c exhibited good herbicidal activities against velvetleaf at a concentration of 30-40 g/hm2. The relationship between structure and herbicidal activity was also discussed. Among unsaturated carboxylates group, butenoate is the most promising one. Amonst them, 4-ethoxy-4-oxobutenyl 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2- nitrobenzoate 5b was identified as the most promising candidate due to its high protoporphyrinogen IX oxidase inhibition effect (pI50 = 6.64) and good herbicidal activity against broadleaf weeds with selectivity to soybean and low toxicity to mammals.
- Yu, Haibo,Yang, Huibin,Cui, Dongliang,Lv, Liang,Li, Bin
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scheme or table
p. 11718 - 11726
(2012/04/04)
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- Bromination of organic allylic compounds by using N,N′-dibromo-N,N′-1,2-ethane diyl bis(2,5-dimethyl benzene sulphonyl)amine
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N,N′-Dibromo-N,N′-1,2-ethane diyl bis(2,5-dimethyl benzene sulphonyl)amine is an efficient brominating agent for bromination of allylic positions of different organic compounds. This reagent in presence of benzoyl peroxide can brominates the allylic positions of organic compounds in ambient conditions in carbon tetrachloride.
- Khazaei, Ardeshir,Vaghei, Ramin Ghorbani,Karkhanei, Ebrahim
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p. 2107 - 2113
(2007/10/03)
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- Consecutive Ring Closure and Neophyl Rearrangement of Some Alkenylaryl Radicals
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The endo cyclization products 4a, 18a, 18b, 25b, and 25c obtained from the reaction of tributylstannane with the bromoarenes 1a, 12a, 12b, 22b, and 22c, respectively, are formed, at least in part, by exo cyclization of the corresponding substituted aryl radicals followed by neophyl rearrangement of the initial products.Kinetic data show that the rearrangement is more rapid for the radicals 15a and 15b containing the naphtalene nucleus than it is for the benzenoid radicals 24b and 24c and is facilitated by the presence of the electron-attracting substituent in 3a.
- Abeywickrema, Anil N.,Beckwith, Athelstan L. J.,Gerba, Sendaba
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p. 4072 - 4078
(2007/10/02)
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